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MetabolomicsIntestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim t...
2023-01-09 | MTBLS4040 | MetaboLights
ProteomicsA multiplex fragment ion-based method for accurate proteome quantification
We developed a multiplex pseudo-isobaric dimethyl labeling (m-pIDL) method for proteome quantification to extend the capacity of the fragment ion-based method to 6-plex by one-step dimethyl labeling with several millidalton and dalton mass differences between precursor ions and enlarging the isolati...
ORGANISM(S): Homo Sapiens Escherichia Coli 
2019-01-22 | PXD012457 |
ProteomicsPDZ domain-containing adaptor protein GIPC1 interacts with the SR-B1 and modulates its expression and lipid transport function
PDZ family protein GIPC1 physically interacts with SR-B1 and regulates SR-B1 expression by promoting SR-B1 protein stability.
ORGANISM(S): Mus Musculus 
2021-03-09 | PXD024595 |
TranscriptomicsGenome-wide transcriptome analysis of two maize inbred lines under drought stress during the seedling stage
To understand the transcriptome changes during drought tolerance in maize, the drought-tolerant line Han21 and drought-sensitive line Ye478, which show substantial differences in drought tolerance at the seedling stage, were selected for this study. Using the GeneChip Maize Genome Arrays, we applied...
ORGANISM(S): Zea mays 
2010-06-16 | E-GEOD-16567 | biostudies-arrayexpress
ProteomicsLC-MS based urine untargeted metabolomic analyses to identify and subdivide urothelial cancer
Urine metabolomics has been a promising technique in the liquid biopsy of urothelial cancer (UC). The comparison of upper tract urothelial cancer (UTUC), lower tract urothelial cancer (BCa), and healthy controls (HCs) needs to be performed to find related biomarkers. In our investigation, urine samp...
ORGANISM(S): Homo Sapiens 
2023-03-02 | PXD040560 |
TranscriptomicsDeterminants of sensitivity to DZNep induced apoptosis in multiple myeloma cells
The 3-Deazaneplanocin A (DZNep), one of S-adenosylhomocysteine (AdoHcy) hydrolase inhibitors, has shown antitumor activities in a broad range of solid tumors and acute myeloid leukemia. Here, we examined its effects on multiple myeloma (MM) cells and found that, at 500 nM, it potently inhibited grow...
ORGANISM(S): Homo sapiens 
2011-07-04 | E-GEOD-26921 | biostudies-arrayexpress
TranscriptomicsComparison of transcriptome profile between wild-type and dao mutant plants
We identified and characterized that the rice Dioxygenase for Auxin Oxidation (dao) mutant displays pleiotropic phenotypes, including indehiscent anthers, sterile pollens, and increased free IAA levels in anthers.We conclude that DAO-mediated auxin catabolism is essential for auxin homeostasis and l...
ORGANISM(S): Oryza sativa Japonica Group 
2012-09-25 | E-GEOD-41097 | biostudies-arrayexpress
ProteomicsProteomic analysis of compounds on pneumonia model mice
We used proteomic analysis to identify proteins with altered expression in mouse lungs, aiming to elucidate their potential mechanisms.
ORGANISM(S): Mus Musculus 
2023-11-30 | PXD047432 |
ProteomicsDifferential proteomic analysis to identify proteins associated with apomeiosis in Boehmeria tricuspis (Hance) Makino
Differential proteomic analysis to identify proteins associated with apomeiosis in Boehmeria tricuspis (Hance) Makino
ORGANISM(S): Boehmeria Tricuspis 
PXD020132 |
ProteomicsBis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell microspheres enabled comprehensive analysis of N-phosphoproteome
Herein, bis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell silica microspheres (SiO2@DpaZn) were tailored for N-phosphopeptide enrichment at pH 7.7. Contributed by the coordination bonding between Zn(II) and phosphate groups with the KD value of 13.14 μM, N-phosphopeptides could be capt...
ORGANISM(S): Escherichia Coli 
2020-02-07 | PXD017423 |
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