Sort   by:  
 Page size 
ProteomicsIP-MS of SpvB and SopD2, four biological replicates in 18 LC-MS/MS experiments.
To screen the host targets of SpvB, we performed IP-MS analyses and measured four biological replicates of paired SpvB and SopD2 samples in 18 LC-MS/MS experiments.
ORGANISM(S): Homo Sapiens 
2023-07-25 | PXD044057 |
ProteomicsShigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation
We demonstrate that OspC effectors enable S. flexneri to evade septin cage entrapment. Mechanistically, OspC catalyzes ADP-riboxanation of SEPT9 at Arg561, a critical site essential for stabilizing septin hetero-oligomers. Notably, ADP-riboxanation or mutation of Arg561 impairs septin polymerization...
ORGANISM(S): Homo Sapiens 
2025-11-04 | PXD070327 |
ProteomicsDeubiquitinase OTULIN dampens RIG-I dependent type I IFN signaling by removing the linear ubiquitination from TRAF6
In this study, we observed a global increase in intracellular linear ubiquitination upon RNA viral infection, suggesting that linear ubiquitination may be a prerequisite for the initiation of antiviral innate immunity. Furthermore, using a combination of various cell lines and in vivo experiments, w...
ORGANISM(S): Homo Sapiens 
2025-11-15 | PXD070809 |
ProteomicsShigella induces stress granule formation by ADP-riboxanation of the eIF3 complex
We utilized a large-scale proteomic profiling strategy to quantitatively measure ADP-riboxanation (and classical ADP-ribosylation) levels of host proteins upon introduction of bacterial effectors. Notably, we identified the eukaryotic translation initiation factor 3 (eIF3) complex as a novel target ...
ORGANISM(S): Homo Sapiens 
2024-01-18 | PXD048666 |
ProteomicsTransfer of the high-quality sugar metabolic model of Aspergillus niger is reliable within the same fungal phylum, but limited for fungi of other phyla
Validation of metabolic models, extrapolated from the reference sugar catabolism genetic network of Aspergillus niger by using an orthology-based approach, of evolutionarily diverse fungi.
ORGANISM(S): Trichoderma Reesei (ncbitaxon:51453) Penicillium Subrubescens (ncbitaxon:1316194) Aspergillus Niger (ncbitaxon:5061) Phanerochaete Chrysosporium Rp-78 (ncbitaxon:273507) Aspergillus Nidulans (ncbitaxon:162425) 
MSV000090441 | MassIVE
ProteomicsSalmonella enterica Serovar Typhimurium transcriptional regulator STM0347 mediates Flagellar Phase Variation via Hin invertase
To elucidate the STM0347 regulon in S. Typhimurium, we performed a quantitative proteomic profiling of stm0347 deletion mutant, compared with its parental WT strain.
ORGANISM(S): Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Sl1344 
2022-06-27 | PXD034943 |
ProteomicsiTRAQ-based Proteome Profiling of Differentially Expressed Proteins in Insulin-resistant Human Hepatocellular Carcinoma
Comparison of Proteomics Changes in hepatocellular carcinoma cells and insulin resistant hepatocellular carcinoma cells
ORGANISM(S): Homo Sapiens 
2022-02-22 | PXD031820 |
ProteomicsDevelopment of Substrate-Directed Activity-Based Probes via Disulfide-Trapping for Site-Specific Interrogation of Nucleosomal Deubiquitination
Activity-based ubiquitin probes (Ub-ABPs) have been instrumental in interrogating deubiquitinases (DUBs), yet conventional Ub-ABPs lack the substrate-specific and site-specific contextual cues required to investigate nucleosomal DUBs, whose activity is tightly regulated by the chromatin environments...
ORGANISM(S): Homo Sapiens 
2025-12-30 | PXD072417 |
ProteomicsLoss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP
The Ras GTPase-activating protein SynGAP interacts with PSD95 to regulate synaptic morphology and function at the postsynaptic density in neurons. Haploinsufficiency of SYNGAP1 has been linked to autism spectrum disorders (ASD) and intellectual disability (ID). While transcriptional and translationa...
ORGANISM(S): Mus Musculus 
2025-05-17 | PXD064040 |
ProteomicscTAGE5 is essential for adipogenesis and adipose tissue development
White adipocytes serve as primary energy reservoirs and their malfunction is linked to different metabolic disorders, yet the mechanisms underlying cellular specialization, a critical step during adipogenesis remain unknown. Here, we reveal the indispensable role of cutaneous T cell lymphoma-associa...
ORGANISM(S): Mus Musculus 
2025-01-07 | PXD059525 |
Sort   by:  
 Page size