Sort   by:  
 Page size 
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
Metabolomics3D DESI mass spectrometry imaging of 51 serial sections from a human liver metastasis
51 serial sections from a single human liver metastasis are made available in this dataset. Four neighbouring sections were placed on a single slide and analysed together. The tissue sections were analysed by desorption electrospray ionisation mass spectrometry imaging (DESI-MSI) according to the pr...
2016-04-28 | MTBLS282 | MetaboLights
MetabolomicsGlobal 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
Liver metabolism is central to human physiology and influences the pathogenesis of common metabolic diseases. Yet, our understanding of human liver metabolism remains incomplete, with much of current knowledge based on animal or cell culture models that do not fully recapitulate human physiology. He...
2024-07-23 | MTBLS10481 | MetaboLights
TranscriptomicsWhole genome analysis for liver metastasis gene signitures in colorectal cancer
Liver metastasis is one of the major causes of death in colorectal cancer (CRC) patients. To understand this process, we investigated whether the gene expression profiling of matched colorectal carcinomas and liver metastases could reveal key molecular events involved in tumor progression and metast...
ORGANISM(S): Homo sapiens 
2008-01-31 | E-GEOD-6988 | biostudies-arrayexpress
ProteomicsProteomics of Primary Uveal Melanoma:Insights to Metastasis and Protein Biomarkers
Uveal melanoma metastases are lethal and remain incurable. Quantitative proteomic analysis of 53 metastasizing and 47 non-metastasizing primary uveal melanoma (pUM) was pursued for insights into UM metastasis and protein biomarkers. The metastatic status of the pUM specimens was defined based on cli...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-15 | MSV000087437 | MassIVE
TranscriptomicsComparison of metastasis-inclined microenvironment (MIM) and metastasis-averse microenvironment (MAM) HCC patients
To determine the role of the hepatic microenvironment in HCC metastasis, we compared the gene expression profiles of 20 noncancerous surrounding hepatic tissues from two HCC patient groups, those with primary HCC together with venous metastasis which we termed a metastasis-inclined microenvironment ...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5093 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis
We performed a genome-wide analysis of lncRNA expression to identify novel targets for the further study of liver metastasis in CRC. Samples obtained from CRC patients were analyzed using Arraystar human 8Ã?60K lncRNA/mRNA v3.0 microarrays chips to find differentially expressed lncRNAs and mRNAs; Th...
ORGANISM(S): Homo sapiens 
2016-05-18 | E-GEOD-75050 | biostudies-arrayexpress
TranscriptomicsComparative profiling of primary colorectal carcinomas and liver metastases
PURPOSE: We sought to identify genes of clinical significance to predict survival and the risk for colorectal liver metastasis (CLM), the most common site of metastasis from colorectal cancer (CRC). PATIENTS AND METHODS: We profiled gene expression in 31 specimens from primary CRC and 32 unmatched s...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-22834 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human liver cancers
To investigate the mechanisms of liver cancer progression and metastasis, we did expression profiling of human liver cancer and benign tissues. Experiment Overall Design: Total RNA was extracted from human liver cancer at Experiment Overall Design: various stages (T1-1~4, T3-1~6), 2 normal human liv...
ORGANISM(S): Homo sapiens 
2008-10-18 | E-GEOD-6222 | biostudies-arrayexpress
TranscriptomicsGene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis
Pathogenesis and factors for determining progression of alcoholic and non-alcoholic steatosis to steatohepatitis with risk of further progression to liver cirrhosis and cancer are poorly understood. In the present study, we aimed to identify potential molecular signatures for discrimination of steat...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-33814 | biostudies-arrayexpress
Sort   by:  
 Page size