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ProteomicsProteome integral solubility alteration assay combined with multi-criteria decision-making analysis for developing adverse outcome pathways
To simplify chemical risk assessment, the adverse outcome pathway (AOP) method has arisen as a framework to predict the impact of chemical exposure on human and environmental health. The development of this predictive tool requires knowledge of the molecular interaction between chemicals and protein...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033056 | Pride
Hepatocytes Bioactive compound Pollutants Proteome integral solubility alteration assay Tcdd Analytical hierarchy process Hepg2 
ProteomicsNonionic surfactants can modify the thermal stability of globular and membrane proteins interfering with the thermal proteome profiling principles to identify protein targets
The membrane proteins are essential targets to understand cellular function. The unbiased identification of membrane protein targets is still the bottleneck for a system- level understanding of cellular response to stimuli or perturbations. It has been suggested to enrich the soluble proteome with m...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-20 | PXD037153 | Pride
Rat liver tissue Igepal Micelles Nonionic surfactants Thermal proteome profiling Nonidet-p40 substitute 
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