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ProteomicsA Vascularized Three-Dimensional Breast Cancer Model: Mimicking the Tumor Microenvironment and Chemoresistance
Tumorigenesis is a complex and dynamic process in which the tumor microenvironment (TME) plays a central role. In solid tumors, the TME contributes to key mechanisms of tumor progression, including metastasis, immune evasion, and resistance to therapies. One major challenge in preclinical cancer res...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-23 | PXD067876 | Pride
Angiogenesis  spheroids  microvascular fragments  tumor microenvironment  3d tumor model 
ProteomicsEnhancing therapeutic efficacy through degradation of endogenous extracellular matrix in primary breast tumor spheroids.
Cancer remains the leading cause of death globally, with nearly 20 million new cases and 10 million fatalities in 2022. The majority (90%) are solid tumors, which are strongly influenced by the tumor microenvironment (TME)—a complex network of blood vessels, connective tissues, immune cells, and the...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD061082 | Pride
Collagen 3d spheroids Breast cancer Extracellular matrix (ecm) Drug penetration Tumor microenvironment (tme) 
ProteomicsProteome profiling of cerebrospinal fluid and machine learning reveal biomarkers of two forms of Alzheimer’s disease characterized by increased or not altered levels of tau
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that impairs memory, cognition, behavior, and other cognitive functions. Despite significant advances in understanding its molecular mechanisms, a definitive cure remains elusive. However, some treatments have the potential to slow...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD063058 | Pride
Alzherimer’s disease – cerebrospinal fluid – proteomics – machine learning – biomarkers 
ProteomicsPriming-Dependent Modulation of Secretome in Placenta- and Adipose-Derived Mesenchymal Stromal/Stem cells: Toward Cell-Free Immunoregenerative Therapies for Osteoarticular Disorders
Age-related bone degeneration is driven by structural deterioration, chronic inflammation, and impaired regenerative capacity, leading to an increased incidence of osteoarticular disorders. Mesenchymal stromal/stem cells (MSCs) have emerged as promising therapeutic candidates due to their immunomodu...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD068866 | Pride
Placenta-derived mscs Exosomal microrna Mesenchymal stromal cells Cytokine priming Adipose-derived mscs Secretome Proteomics Extracellular vesicles Osteogenesis Chondrogenesis 
ProteomicsComputationally guided prioritization of microRNA therapeutics for metabolic dysfunction-associated steatohepatitis: inhibition of hepatic stellate cell activation
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease characterized by chronic inflammation and fibrosis, for which effective therapies remain limited. Given the multifactorial nature of MASH, therapeutic approaches capable of modulating complex regulatory networks a...
ORGANISM(S): Homo sapiens (Human) 
2026-09-02 | PXD073651 | Pride
Type i collagen-α1 Lx-2 cells Hepg2 cells Fibrosis Mash Mirna mimics 
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