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ProteomicsLC-MS and gel-based comparison of DPSCs and PDLSCs
Tooth pulp contains various types of cells such as endothelial cells, neurons, fibroblasts, osteoblasts, osteoclasts, and odontoblasts. As well as cells that are called "postnatal dental pulp stem cells" (DPSCs). Also, four more types of dental MSC-like populations were identified and characterized:...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD027719 | Pride
Osteogenic differentiation Mscs Timstof pro Pdlscs 2d dige Dpscs Ion mobility 
ProteomicsProteolytic degradation is the culprit behind a bioprosthetic heart valve failure
Whereas the risk factors for structural valve deterioration (SVD) of glutaraldehyde (GA)- treated bioprosthetic heart valves (BHVs) are well-studied, those responsible for the failure of next-generation BHVs fixed with alternative chemicals remain largely unknown. Here, we collected 11 ethylene glyc...
ORGANISM(S): Homo sapiens (Human) 
2022-12-25 | PXD035113 | Pride
Human Pasef Timstof pro Calcific aortic valve disease Bioprosthetic heart valve 
ProteomicsCrenigacestat inhibits osteogenic differentiation of human valve interstitial cells and seems promising for treatment of cardiovascular calcification
Vascular calcification is common pathology various forms of which presented in the half of humans. Calcific aortic valve disease (CAVD) is one of the most dangerous forms of vascular calcification. Despite high mortality there is no target therapy against CAVD. Thus, we tested crenigacestat (LY30394...
ORGANISM(S): Homo sapiens (Human) 
2022-10-04 | PXD029632 | Pride
Valve intersticial cells Timstof pro Vascular calcification Ly3039478 Notch inhibitors Crenigacestat Calcific aortic valve disease Shotgun proteomics 
ProteomicsImpact of fibrillar collagen scaffold on corneal stromal fibroblasts protein expression
The human cornea relies on its extracellular matrix (ECM) properties, with corneal stromal fibroblasts (CSFs) crucial for ECM remodeling. We studied the effects of nanofibrillar materials on CSFs using a decellularized human amniotic membrane (dHAM) and fibrillar collagen scaffold (FCS). FCS enhance...
ORGANISM(S): Homo sapiens (Human) 
2024-09-02 | PXD048096 | Pride
Fibrillar collagen scaffold Timstof pro Dda-pasef Corneal keratocytes Focal adhesion Extracellular matrix 
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