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Dental stem cells isolated from oral tissues have been shown to provide with high proliferation ability and multi-lineage differentiation potential. Although the dental stem cells possess the potential of nerve regeneration, the specific expression profile of dental pulp stem cells (DPSCs) and perio...
ORGANISM(S): Homo sapiens (Human) 
2021-06-10 | PXD021997 | Pride
Our previous study (Environ Pollut. 2023;323:121307) has indicated that Glucose-dependent insulinotropic polypeptide receptor (GIPR) and Glucagon-like peptide-1 receptor (GLP1R) are down-regulated in periodontal ligament stem cells (PDLSCs) by cigarette and E-cig. In the current study, we focus on i...
ORGANISM(S): Homo sapiens 
Cald1 regulates osteogenic differentiation of PDLSCs.
Our previous study (Environ Pollut. 2023;323:121307) has indicated that Glucose-dependent insulinotropic polypeptide receptor (GIPR) is down-regulated in periodontal ligament stem cells (PDLSCs) by cigarette and E-cig. In the current study, ChIP-seq was conducted to study the genome-wide occupancies...
ORGANISM(S): Homo sapiens 
We have observed that the expression of IFIT1, IFIT2, IFIT3 and the other genes related interferon are all elevated by GLP1R knockdown whereas reduced by GLP1RA and 2GRA in multiple lineages differentiation systems of PDLSCs. It was reported that IFIT proteins could block the formation of 43S pre-in...
ORGANISM(S): Homo sapiens 
Transcriptome sequencing of PDLSCs induced by GIPR and GLP1R alteration
RNA sequencing of human periodontal ligament stem cells (PDLSCs) with Illumina HiSeq2000
To explore underlying mechanisim of which Cald1 regulates osteogenic differentiation of PDLSCs, RNA -seq was performed on PDLSCs treated with NC shRNA and Cald1 shRNA respectively.
ORGANISM(S): Homo sapiens 
2025-06-30 | GSE236009 | GEO
Tooth pulp contains various types of cells such as endothelial cells, neurons, fibroblasts, osteoblasts, osteoclasts, and odontoblasts. As well as cells that are called "postnatal dental pulp stem cells" (DPSCs). Also, four more types of dental MSC-like populations were identified and characterized:...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD027719 | Pride
Genome-wide occupancies of multiple transcription activators in PDLSCs induced by GIPRA
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