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ProteomicsActivity modulation in anaerobicribonucleotide reductases: nucleotidebinding: HDX-MS data
A small, nucleotide-binding domain, the ATP-cone, is found at the N-terminus of mostribonucleotide reductase (RNR) catalytic subunits. By binding ATP or dATP it regulates theenzyme activity of all classes of RNR. Functional and structural work on aerobic RNRs hasrevealed a plethora of ways in which ...
ORGANISM(S): Prevotella corporis DSM 18810 = JCM 8529 
2024-08-10 | PXD047943 | Pride
Anaerobicribonucleotide reductases Hdx-ms 
UnknownEarth orbital rhythms links timing of Deccan trap volcanism phases and global climate change.
Not available
S-EPMC11887795 | biostudies-literature
UnknownThe structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis.
Not available
S-EPMC9178029 | biostudies-literature
UnknownNanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction.
Not available
S-EPMC11850616 | biostudies-literature
UnknownThe Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active Site.
Not available
S-EPMC4493059 | biostudies-literature
TranscriptomicsTNFalpha and IL1beta stimulate differential gene expression in endometrial stromal cells
Cytokines are implicated in the development of inflammatory diseases such as endometriosis. This project was designed to test the hypothesis that specific cytokines that are secreted by macrophages, such as tumor necrosis factor ? (TNF?) and interleukin 1 beta (IL1?), cause gene expression changes i...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-40007 | biostudies-arrayexpress
ProteomicsRegulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15
PARP15 is a mono-ADP-ribosyltransferase with unknown functions. Its evolutionary relationship with PARP14 suggests roles in antiviral defense; its ability to modify RNA and localization to stress granules point to functions in the regulation of translation. PARP15 also modifies itself and other prot...
ORGANISM(S): Homo sapiens (Human) 
2025-10-02 | PXD061403 | Pride
Hdx-ms Parp15 
TranscriptomicsGene expression of human skin fibroblast cells derived from hypospadias patients in response to low-dose bisphenol A exposure
To better understand the molecular basis of the reproductive health effects of bisphenol A (BPA) on humans, a genome-wide screening was applied to identify novel targets of low-dose bisphenol A exposure in huamn skin fibroblast cells (hSFCs) derived from hypospadias patient children. Three hSFCs wer...
ORGANISM(S): Homo sapiens 
2012-01-13 | E-GEOD-35034 | biostudies-arrayexpress
TranscriptomicsA Comparative Study of Genome Wide Transcriptional Profiles of Primary Hepatocyte in In Vitro Cultures
The liver is one of most important organs in our bodies. It performs many essential functions including metabolism, synthesis, secretion, detoxification, and storage. Hepatocytes are the principal cell type in the liver and are involved in multiple liver-specific functions. There have been several e...
ORGANISM(S): Rattus norvegicus 
2010-06-08 | E-GEOD-20659 | biostudies-arrayexpress
UnknownThe engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Not available
S-EPMC8980021 | biostudies-literature
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