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ProteomicsGlobal proteome remodeling during ER stress involves Hac1-driven expression of long undecoded transcript isoforms
Cellular stress responses often require transcription-based activation of gene expression to promote cellular adaptation. Whether general mechanisms exist for stress-responsive gene down-regulation is less clear. A recently defined mechanism enables both up- and down-regulation of protein levels for...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-06-12 | MSV000082454 | MassIVE
UnknownANDREW: A Multicenter, Prospective, Observational Study in Patients with Type 2 Diabetes on Persistent Treatment with Dulaglutide.
Not available
S-EPMC7547933 | biostudies-literature
ProteomicsGIGANTEA interaction proteomics time course
Interaction proteomics time course over 24h every 4h, looking for novel interactors of the circadian clock and flowering time protein GIGANTEA. Plants expressing 35S:GIGANTEA:3xFlag6His were used, as well as WT plants for a background control.
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2017-07-03 | MSV000081217 | MassIVE
TranscriptomicsLong noncoding RNA expression in several hematopoietic progenitor and differentiated cell populations using a custom Agilent microarray
Mammals express thousands of long noncoding (lnc) RNAs, a few of which are shown to function in tissue development. However, the entire repertoire of lncRNAs and the extent to which they regulate biological processes in different tissues and species are not defined. Indeed, most lncRNAs are not cons...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-51892 | biostudies-arrayexpress
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
TranscriptomicsLongSAGE transcriptome profiling in the widespread marine coccolithophore Emiliania huxleyi
The abundant and widespread coccolithophore Emiliania huxleyi plays an important role in mediating CO2 exchange between the ocean and the atmosphere through its impact on marine photosynthesis and calcification. Here, we use long serial analysis of gene expression (SAGE) to identify E. huxleyi genes...
ORGANISM(S): Emiliania huxleyi CCMP1516 
2007-07-07 | E-GEOD-8376 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of long-lived C.elegans daf-2 pathway mutants with wild type/short-lived mutants
Comparison of long-lived daf-2 pathway mutants with wild type/short-lived mutants. A: age-1 fer-15; fem-1 vs. fer-15; fem-1. B: age-1 fer-15; fem-1 vs. fer-15; fem-1. C: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. D: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. E: daf-16::gfp in daf...
ORGANISM(S): Caenorhabditis elegans 
2003-07-17 | E-MEXP-7 | biostudies-arrayexpress
TranscriptomicsIdentification of a stable molecular signature in breast tumor endothelial cells that persists ex vivo
Long-term, in vitro propagation of tumor-specific endothelial cells (TEC) allows for ex vivo functional studies and gene expression profiling of clonally-derived, well-characterized subpopulations. Using a genetically-engineered mouse model (GEMM) of mammary adenocarcinoma (C3-TAg), we have optimize...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-50555 | biostudies-arrayexpress
ProteomicsArabidopsis circadian proteomics and phosphoproteomics in Col0 and CCA1-Ox
Proteomics and phosphoproteomics analyses of circadian time course samples of Arabidopsis thaliana rosettes (22 DAS) in constant light. Two independent experiments, with global proteomics and phosphoproteomics analyses for each. Experiment I has a time point every 4h from ZT12 to ZT32, experiment 2 ...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2018-03-16 | MSV000082175 | MassIVE
TranscriptomicsRNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice.
The goal was to find genes which are differentially expressed between the naked mole-rat (Heterocephalus glaber) and the wild-type mice liver tissue. The genes which are most differentially expressed may provide a clue for the remarkable differences between naked mole-rat and mouse in terms of longe...
ORGANISM(S): Heterocephalus glaber 
2011-11-07 | E-GEOD-30764 | biostudies-arrayexpress
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