Sort   by:  
 Page size 
ProteomicsCombined transcriptome and proteome profiling for role of pfEMP1 in antimalarial mechanism of action of dihydroartemisin
Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in endemic countries. However, the mechanism of action of artemisinin is unclear, and dru...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-02-15 | PXD028062 | Pride
Mode of action Irbc membrane proteome Dihydroartemisin Malaria 
UnknownChiral nanoprobes for targeting and long-term imaging of the Golgi apparatus.
Not available
S-EPMC5643954 | biostudies-literature
TranscriptomicsTime-resolved immune dynamics in rheumatoid arthritis under methotrexate therapy
Methotrexate (MTX) serves as the primary treatment for rheumatoid arthritis (RA), though its mechanism of action is not yet fully understood. The goal of this study was to map the cellular and molecular changes triggered by MTX across different points in time. Using a prospective longitudinal design...
ORGANISM(S): Homo sapiens 
2026-07-01 | E-MTAB-17153 | biostudies-arrayexpress
TranscriptomicsSensitive and robust gene expression changes in fish exposed to estrogen - a microarray approach
Background
Vitellogenin is a well established biomarker for estrogenic exposure in fish. However, effects on gonadal differentiation at concentrations of estrogen not sufficient to give rise to a measurable vitellogenin response suggest that more sensitive biomarkers would be useful. Induction of...
ORGANISM(S): Oncorhynchus mykiss 
2007-07-24 | E-MEXP-1149 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of CD4 T cells in treatment-naive HIV
In this study, treatment-naive HIV, HCV mono-/co-infected individuals with CD4+ T cell counts >300/?l were recruited and their global gene expression profiles were investigated. By gene set enrichment analysis (GSEA), we revealed that gene sets of cell cycle progression, innate immune response and s...
ORGANISM(S): Homo sapiens 
2012-07-01 | E-MEXP-3601 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Assay of CD8 2012-05-15
In this study, Genome-wide transcriptomes of CD8+ T cells from HCV/HIV co-infected or mono-infected treatment-naive individuals were analyzed by using microarray assays. Pairwise comparisons were performed and differentially expressed genes were identified followed by quantitative real time PCR (qRT...
ORGANISM(S): Homo sapiens 
2012-05-17 | E-MEXP-3635 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain samples from human control and schizophrenia patients who were treated with either typical, atypical or no antipsychotic medication
Multiple studies have shown that brain gene expression is disturbed in subjects suffering from schizophrenia. However, disentangling disease effects from alterations caused by neuroleptics is a challenging task.
To address the issues of disease heterogeneity and the effect of antipsychotic medi...
ORGANISM(S): Homo sapiens 
2007-12-06 | E-MEXP-857 | biostudies-arrayexpress
UnknownMEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development.
Not available
S-EPMC5910578 | biostudies-literature
TranscriptomicsWaterborne beclomethasone diproprionate affects fish while its metabolite beclomethasone is not taken up
Investigation of transcriptome expression changes in liver tissue of rainbow trout exposed beclomethasone diproprionate (1 M-BM-5g/L nominal concentration) in a flow through set up for 2 weeks A four chip (x12) study using total RNA prepared from liver.
ORGANISM(S): Oncorhynchus mykiss 
2014-12-10 | E-GEOD-57219 | biostudies-arrayexpress
TranscriptomicsNA-Seq reveals dynamic changes of gene expression in key stages of intestine regeneration in the sea cucumber Apostichopus japonicus.
Sea cucumbers (Holothuroidea; Echinodermata) have the capacity to regenerate lost tissues and organs.We used RNA-Seq to determine gene expression profiles associated with intestinal regeneration in A. japonicus at 3, 7, 14 and 21 days post evisceration (dpe) At least 15 individuals per stage, at 3,...
ORGANISM(S): Apostichopus japonicus 
2015-01-01 | E-GEOD-44995 | biostudies-arrayexpress
Sort   by:  
 Page size