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TranscriptomicsTranscripts induced by recombinant IFNa in healthy blood monocytes at different time points
To explore the full extent of IFN-regulated transcriptional changes, we exposed monocytes from two healthy donors to recombinant type I IFN (IFN-M-NM-12b) in vitro. RNA was extracted at different incubation times (1, 6, 24, 48 and 72 hrs) and the expression data was normalized to that of monocytes c...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46911 | biostudies-arrayexpress
TranscriptomicsSLE serum induced transcripts regulated by IFNa2b
To explore the full extent of IFN-regulated transcriptional changes, we exposed monocytes from two healthy donors to recombinant type I IFN (IFN-M-NM-12b) in vitro. RNA was extracted at 6 hrs and the expression data was normalized to that of monocytes cultured with medium. Blood monocytes isolated f...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46921 | biostudies-arrayexpress
GenomicsAntisense long non-coding RNAs are deregulated in skin tissue of patients with systemic sclerosis
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and multiple organs of which the pathogenesis is poorly understood. Here we studied differentially expressed coding and non-coding genes in relation to SSc pathogenesis with a specific focus on antisense non-coding R...
EGAS00001002751 | EGA
MetabolomicsLC-MS based plant metabolic profiles of thirteen grassland species grown in diverse neighbourhoods
In plants, secondary metabolite profiles provide a unique opportunity to explore seasonal variation and responses to the environment. These include both abiotic and biotic factors. In field experiments, such stress factors occur in combination. This variation alters the plant metabolic profiles in y...
2020-12-23 | MTBLS679 | MetaboLights
TranscriptomicsMolecular Rejuvenation of Gene Expression Pattern of Photoaged and Intrinsically Aged Human Skin by Broadband Light Treatment
Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply deep sequencing of RNA 3' ends ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin ...
ORGANISM(S): Homo sapiens 
2012-07-30 | E-GEOD-39170 | biostudies-arrayexpress
TranscriptomicsMaternal age effect on mouse oocytes: new biological insight from proteomic analysis
The long-standing view of 'immortal germ line versus mortal soma' poses a fundamental question in biology concerning how oocytes age in molecular terms. A mainstream hypothesis is that maternal aging of oocytes has its roots in gene transcription. Investigating the proteins resulting from mRNA trans...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-42959 | biostudies-arrayexpress
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
GenomicsDAC: Antisense long non-coding RNAs are deregulated in skin tissue of patients with systemic sclerosis
Data Access Committee EGAC00001000788
EGAC00001000788 | EGA
TranscriptomicsInduction of adaptive changes in the Streptococcus agalactiae transcriptome by human blood
In the present investigation, we conducted a bacterial transcriptome dynamics analysis during GBS incubation with human blood. We observed a large modification in the expression of genes involved in transcriptional regulation and in the metabolism of carbohydrates, purins/pyrimidins and inorganic io...
ORGANISM(S): Streptococcus agalactiae 
2008-10-31 | E-GEOD-11705 | biostudies-arrayexpress
TranscriptomicsSystemic lupus erythematosus
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46923 | biostudies-arrayexpress
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