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TranscriptomicsTranscripts induced by recombinant IFNa in healthy blood monocytes at different time points
To explore the full extent of IFN-regulated transcriptional changes, we exposed monocytes from two healthy donors to recombinant type I IFN (IFN-M-NM-12b) in vitro. RNA was extracted at different incubation times (1, 6, 24, 48 and 72 hrs) and the expression data was normalized to that of monocytes c...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46911 | biostudies-arrayexpress
GenomicsAntisense long non-coding RNAs are deregulated in skin tissue of patients with systemic sclerosis
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and multiple organs of which the pathogenesis is poorly understood. Here we studied differentially expressed coding and non-coding genes in relation to SSc pathogenesis with a specific focus on antisense non-coding R...
EGAS00001002751 | EGA
MetabolomicsLC-MS based plant metabolic profiles of thirteen grassland species grown in diverse neighbourhoods
In plants, secondary metabolite profiles provide a unique opportunity to explore seasonal variation and responses to the environment. These include both abiotic and biotic factors. In field experiments, such stress factors occur in combination. This variation alters the plant metabolic profiles in y...
2020-12-23 | MTBLS679 | MetaboLights
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
GenomicsDAC: Antisense long non-coding RNAs are deregulated in skin tissue of patients with systemic sclerosis
Data Access Committee EGAC00001000788
EGAC00001000788 | EGA
TranscriptomicsMolecular Rejuvenation of Gene Expression Pattern of Photoaged and Intrinsically Aged Human Skin by Broadband Light Treatment
Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply deep sequencing of RNA 3' ends ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin ...
ORGANISM(S): Homo sapiens 
2012-07-30 | E-GEOD-39170 | biostudies-arrayexpress
TranscriptomicsInduction of adaptive changes in the Streptococcus agalactiae transcriptome by human blood
In the present investigation, we conducted a bacterial transcriptome dynamics analysis during GBS incubation with human blood. We observed a large modification in the expression of genes involved in transcriptional regulation and in the metabolism of carbohydrates, purins/pyrimidins and inorganic io...
ORGANISM(S): Streptococcus agalactiae 
2008-10-31 | E-GEOD-11705 | biostudies-arrayexpress
TranscriptomicsDifferential Streptococcus agalactiae gene expression in human blood according to the blood donors
In the present investigation, we conducted a bacterial transcriptome dynamics analysis during GBS incubation with human blood. We observed large modification in the expression of numerous genes, but GBS transcriptome was different with the blood of one donor. More genes were up-regulated and less do...
ORGANISM(S): Streptococcus agalactiae 
2009-06-01 | E-GEOD-12201 | biostudies-arrayexpress
Genomicsena-DATASET-LUMC-SASC-04-12-2017-12:12:33:008-298 - samples
Patient information SSc patients were recruited at the Department of Rheumatology of the Leiden University Medical Center (Leiden, The Netherlands). All patients met the American Rheumatism Association classification criteria for SSc (Subcommittee for scleroderma criteria 1980), and were classified ...
EGAD00001003832 | EGA
TranscriptomicsSMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
Characterization of the selectivity of SMN splicing modifiers in SMA type I fibroblasts by RNASeq In total 12 samples were analyzed, divided into four distinct groups (treated with SMN-C3 @ 500 nM; controls for SMN-C3; treated with SMN-C1 @ 100 nM; controls for SMN-C1) containing 3 replicates each.
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-62540 | biostudies-arrayexpress
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