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MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
UnknownTao-1 is a negative regulator of microtubule plus-end growth.
Not available
S-EPMC2915876 | biostudies-literature
ProteomicsAn unconventional integrin b3 and CD103 heterodimer improves the anti-tumor immunity of tissue-resident T cells
Current cancer immunotherapies promote recovery of CD103+ tissue-resident memory T cells (Trm) population of the tumor-infiltrating T lymphocytes (TILs). However, not all treated patients exhibit improved anti-tumor immunity and survival, likely due to the immunophenotypical diversity among the C...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD031794 | Pride
Xcr1 Granulysin Itgb3 Tissue-resident Cancer immunotherapy Amino acids Cancer-specific t cells 
ProteomicsViral control by a unique cytotoxic SARS-CoV-2 spike protein-specific CD4+ T cell population
Little is known of the role of cytotoxic CD4+ T-cells (CTLs) in the control of human viral replication. Here, we investigate CD4+ T-cell responses to three immunodominant SARS-CoV-2 epitopes identified in our study cohort, and evaluate cytotoxic activity and antiviral cytokine production in response...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2025-08-15 | PXD042469 | Pride
Human Epitotpes Sars-cov-2 Cd4+ tcells Lc-ms/ns 
UnknownLeachability and Health Risk Assessment of Cadmium and Other Heavy Metals in Agricultural Soils from the Mae Tao Watershed, Northern Thailand.
Not available
S-EPMC12390624 | biostudies-literature
UnknownLong-term prognostic significance of interleukin-17-producing T cells in patients with non-small cell lung cancer.
Not available
S-EPMC6609818 | biostudies-literature
TranscriptomicsCXCR5+ Follicular Cytotoxic T cells Control Viral Infection in B Cell follicles
Lymphocytic Choriomeningitis Virus (LCMV) specific CD8+ T cells (P14) were transferred into congenic WT mice followed by LCMV(DOCILE) infection. CXCR5-expressing (CXCR5+) or CXCR5 non-expressing (CXCR5-) P14 were purified on day 8 after infection, and total mRNA were sequenced from these populations...
ORGANISM(S): Mus musculus 
2016-07-31 | E-GEOD-76279 | biostudies-arrayexpress
MetabolomicsA next-generation yeast chassis: comprehensive characterization of a robust fast-growing Saccharomyces cerevisiae

Robust and efficient hosts are necessary to facilitate advances in biotechnology. We unveil Saccharomyces cerevisiae strain XP as a promising new microbial chassis owing to its high growth rate and robustness. This strain has a doubling time of 48.2 min, which is 12.8 min faster than the...

2024-09-26 | MTBLS7328 | MetaboLights
UnknownCarvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice.
Not available
S-EPMC6827914 | biostudies-literature
UnknownAblative Radiotherapy Doses Lead to a Substantial Prolongation of Survival in Patients With Inoperable Intrahepatic Cholangiocarcinoma: A Retrospective Dose Response Analysis.
Not available
S-EPMC4980564 | biostudies-literature
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