Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of rat AFTER IN vivo administration OF Gamendazole AND Lonidamine
rat testis time changes; Experimental details are found at Tash et al, Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP-90, eEF1A, and stimulates IL-1 transcription in Sertoli cells, Biol. Reprod. (2007) under review Experiment Overall Design: Adult male r...
ORGANISM(S): Rattus rattus 
2008-04-10 | E-GEOD-8485 | biostudies-arrayexpress
GenomicsLonidamine enhances the oncolytic effect of M1 virus through inhibiting antiviral immune response and potentiating ER stress mediated apoptosis
Lonidamine enhances the oncolytic effect of M1 virus through inhibiting antiviral immune response and potentiating ER stress mediated apoptosis
PRJNA640682 | ENA
ProteomicsStudy on the mechanism of action of the Pt(IV) complex with lonidamine ligands by ultrafast chemical proteomics
Platinum (II) complexes such as cisplatin among the few others are well-known and approved for clinical use as anticancer metal-based drugs. In spite of their successful and wide acceptance, the respective chemotherapy is associated with severe side effects and the ability of tumors to quickly devel...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD058413 | Pride
Dual action antitumor therapy Thermal proteome profiling Mechanism of action Expression proteomics Platinum complexes Ultrafast proteomics 
TranscriptomicsLonidamine enhances the oncolytic effect of M1 virus through inhibiting antiviral immune response and potentiating ER stress mediated apoptosis
Gene set enhancement analysis (GSEA) revealed that M1 treatment upregulates glycolysis and hypoxia pathway in hallmark gene sets. GSEA revealed that Lonidamine strongly inhibited the IFN-α and IFN-β response pathways after M1 virus infection. GSEA showed that gene sets in unfolded protein response, ...
ORGANISM(S): Homo sapiens 
2020-11-16 | GSE152876 | GEO
ProteomicsUltrafast proteomics revealed everolimus-induced inhibition of 20S proteasome subunit
In this study, we compare the proteomic responses of three cell lines (A549, HCT116, and MCF-7) to treatment with three antitumor drugs (bortezomib, everolimus, and lonidamine), with a particular focus on the effects on the ubiquitin-proteasome system. Liquid chromatography–mass spectrometry (LC-MS)...
ORGANISM(S): Homo sapiens (Human) 
2026-07-20 | PXD060076 | Pride
Lonidamine Directms1 Lc-ms Bortezomib Everolimus Chemical proteomics Cell line 
UnknownRu(III) Complexes with Lonidamine-Modified Ligands.
Not available
S-EPMC8707700 | biostudies-literature
UnknownNew Organometallic Ru(II) Compounds with Lonidamine Motif as Antitumor Agents.
Not available
S-EPMC10223346 | biostudies-literature
UnknownLonidamine, a Novel Modulator for the BvgAS System of Bordetella Species.
Not available
S-EPMC11873758 | biostudies-literature
UnknownLonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity.
Not available
S-EPMC7607643 | biostudies-literature
UnknownA thermoresponsive nanocomposite integrates NIR-II-absorbing small molecule with lonidamine for pyroptosis-promoted synergistic immunotherapy.
Not available
S-EPMC11007887 | biostudies-literature
Sort   by:  
 Page size