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TranscriptomicsMapping of mononucleosomal DNA in wild type Drosophila
Crosslinked chromatin from wild-type flies was digested with micrococcal nuclease. Mononucleosomal DNA was gel-purified and hybridized to Affymetrix tiling arrays.
ORGANISM(S): Drosophila melanogaster 
2008-05-20 | E-MEXP-1519 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Drosophila DNA to identify nucleosomes bound by RNA polymerase II
Crosslinked chromatin was digested with Micrococcal nuclease and immunopurified for Rpb3, a subunit of RNA Polyermase II. chIP'd DNA was hybridized to Drosophila tiling arrays and nucleosomes that were bound by Pol II were mapped.
ORGANISM(S): Drosophila melanogaster 
2008-05-20 | E-MEXP-1515 | biostudies-arrayexpress
TranscriptomicsCGH profiling of Bacillus cereus isolates from the CDC historical strain collection
The goal of this study is the discovery of (a) meaningful phylogenomic relationships among members of this B. cereus/B. anthracis group, and (b) reliable gene-phenotype associations, e.g. recognition of links between genomic traits and the ability of certain strains to cause various forms of disease...
ORGANISM(S): Bacillus anthracis 
2010-05-20 | E-GEOD-19125 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of late exponential vs. stationary phase cultures using a custom designed Pseudo-nitzschia multiseries (Ps-n) cDNA microarray
Pseudo-nitzschia multiseries (Ps-n) is a toxigenic marine diatom that produces the neurotoxin, domoic acid. We screened for candidate genes that may be involved in domoic acid production by determining changes in transcript profiles in Ps-n cultures that were in late exponential (low-domoic-acid-pro...
ORGANISM(S): Pseudo-nitzschia multiseries 
2013-09-08 | E-GEOD-46845 | biostudies-arrayexpress
TranscriptomicsPausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation: ChIP-chip data
Metazoan transcription is controlled through either coordinated recruitment of transcription machinery to the gene promoter, or subsequently, through regulated pausing of RNA polymerase II (Pol II) in early elongation. We report that a key difference between genes that use these distinct regulatory ...
ORGANISM(S): Drosophila melanogaster 
2010-10-18 | E-GEOD-20471 | biostudies-arrayexpress
TranscriptomicsDNA profiling of serous ovarian and Fallopian tube carcinomas with array CGH and MLPA
Primary serous ovarian carcinoma (OVCA) and serous Fallopian tube carcinoma (FTC), both belonging to the BRCA-linked tumour spectrum, share many properties and are treated similarly. However, a detailed molecular comparison has been lacking. We hypothesized that comparative genomic studies of serous...
ORGANISM(S): Homo sapiens 
2008-07-08 | E-GEOD-12040 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 10 sample types: normal colon tissue, non cancerous adenomas, Dukes B carcinomas, Dukes C carcinomas, Dukes D carcinomas, and liver metastases, see also E-TIGR-14, E-TIGR-15
This study was designed to find patterns of gene expression in colon cancer samples that correlate with clinical stage. Ten samples were profiled from each of the following sample types: normal colon tissue, noncancerous adenomas, Dukes B carcinomas, Dukes C carcinomas, Dukes D carcinomas, and liver...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-TIGR-14 | biostudies-arrayexpress
TranscriptomicsWhole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to MycobacteriumM-BM- bovis infection in vitro
Background: MycobacteriumM-BM- bovis, the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during infection via a diverse range of mechanisms that subvert the host immune response. In the current study, we have analysed and compared the tr...
ORGANISM(S): Bos taurus 
2013-03-26 | E-GEOD-45439 | biostudies-arrayexpress
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