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ProteomicsProteomic and cellular responses against mutagenesis
Endogenous stress represents a major source of genome instability, but is in essence difficult to apprehend. Incorporation of labeled radionuclides into DNA constitutes a tractable model to analyze cellular responses to endogenous attacks. Here we show that incorporation of [3H]thymidine into CHO ha...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2016-07-15 | PXD003542 | Pride
Endogenous stress Tritium Oxidative stress Proteomic Mutagenesis Low doses 
TranscriptomicsTranscriptional Activity in Lymph Nodes During the Initiation and Progression of Autoimmune Encephalomyelitis
NOD mice (8- to 13-wk-old) were bred and maintained at the La Trobe University Central Animal House (Bundoora, Melbourne, Australia). All experiments were conducted in accordance with the Australian code of practice for the care and use of animals for scientific purposes (National Health and Medical...
ORGANISM(S): Mus musculus 
2008-04-03 | E-GEOD-7461 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human primary fibroblasts treated with 250µM HU versus untreated primary fibroblats
We analyzed the transcription response of human primary fibroblasts exposed (3 days) to a non blocking dose of HU (250µM). This dose of HU generates a replication stress, but the canonical DDR is not fully activated and the cells still proliferate and synthetize DNA; however, cells respond to such l...
ORGANISM(S): Homo sapiens 
2019-12-20 | E-MTAB-8605 | biostudies-arrayexpress
TranscriptomicsIdentification of ETO2-GLIS2 transcriptional targets
Acute megakaryoblastic leukemia (AMKL) is a subtype of leukemia primarily diagnosed in childhood and generally associated with poor prognosis. Genetic alterations found in de novo childhood AMKL include the OTT-MAL fusion, MLL and NUP98 fusions and the recently identified ETO2-GLIS2 fusion that invo...
ORGANISM(S): Homo sapiens 
2017-05-05 | E-MTAB-4332 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of heart samples of myotonic dystrophic (DM1) patients
Analysis of alternative splicing in heart (left ventricles) samples of 3 adult DM1 patients versus 3 adult controls PolyA RNA from left ventricles (heart) of 3 controls and 3 DM1 patients were analysed by massive parrallel sequencing
ORGANISM(S): Homo sapiens 
2015-04-14 | E-GEOD-67812 | biostudies-arrayexpress
TranscriptomicsExpression profile of non-muscle invasive (superficial) bladder carcinoma
Gene expression profiling of 82 human non-muscle invasive bladder carcinoma and 4 normal bladder samples, for a total of 86 tissues. A Cartes díIdentite des Tumeurs (CIT) study from the 'Institut Curie' and the french 'Ligue Nationale Contre le Cancer' (http://cit.ligue-cancer.net/).
ORGANISM(S): Homo sapiens 
2015-01-01 | E-MTAB-1940 | biostudies-arrayexpress
UnknownEfficacy and Safety of Ticagrelor and Aspirin in Patients With Moderate Ischemic Stroke: An Exploratory Analysis of the THALES Randomized Clinical Trial.
Not available
S-EPMC8430457 | biostudies-literature
UnknownBrand-specific estimates of influenza vaccine effectiveness for the 2021-2022 season in Europe: results from the DRIVE multi-stakeholder study platform.
Not available
S-EPMC10399959 | biostudies-literature
GenomicsIdentification of ETO2-GLIS2 targets by ChIP-sequencing
Acute megakaryoblastic leukemia (AMKL) is a subtype of leukemia primarily diagnosed in childhood and generally associated with poor prognosis. Genetic alterations found in de novo childhood AMKL include the OTT-MAL fusion, MLL and NUP98 fusions and the recently identified ETO2-GLIS2 fusion that invo...
ORGANISM(S): Homo sapiens 
2017-05-22 | E-MTAB-4367 | biostudies-arrayexpress
UnknownDamaging de novo missense variants in EEF1A2 lead to a developmental and degenerative epileptic-dyskinetic encephalopathy.
Not available
S-EPMC7292794 | biostudies-literature
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