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Although Candida albicans and Candida dubliniensis are most closely related, both species significantly behave differently with respect to morphogenesis and virulence. In order to gain further insight into the divergent routes for morphogenetic adaptation in both species, we investigated qualitative...
ORGANISM(S): Candida albicans 
Glioblastoma, the most frequent primary malignant brain tumor in adults, is characterized by profound yet dynamic hypoxia and nutrient depletion. To sustain survival and proliferation, tumor cells are compelled to acquire metabolic plasticity with the induction of adaptive metabolic programs. We hav...
ORGANISM(S): Homo sapiens (Human) 
2025-01-19 | PXD046679 | Pride
Proteomic analysis of LNT-299 cells.In this experimental study, we investigated the role of the AMPK-mediated stress response in human GB cells. Mimicking the conditions of the tumour microenvironment we deprived GB cells of glucose and oxygen to characterize metabolic effects and to delineate the r...
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD055976 | Pride
The ubiquitin system regulates eukaryotic physiology by modifying specific substrate proteins. Substrate recognition and the assembly of ubiquitin signals are determined by ubiquitin ligases, some of which also modify non-protein biomolecules. Here we expand this substrate realm, revealing that the ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-10 | PXD067088 | Pride
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