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ProteomicsMistranslation from endogenous tRNA variants in human pan-genome cell lines
Errors in protein synthesis are thought to be rare, yet cells representing the diversity of life tolerate greatly elevated levels of error. One source of translation error in humans are anticodon mutations in transfer RNAs (tRNAs). We found a tRNA Ser AGA -2-3 variant (G35A) that occurs in 2% of the...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD064886 | Pride
Mistranslation Trna variants Translation error 
TranscriptomicsTranscriptomic analysis of autistic brain reveals convergent molecular pathology [high-throughput sequence data]
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental condition characterized by marked genetic heterogeneity. Thus, a fundamental question is whether autism represents an aetiologically heterogeneous disorder in which the myriad genetic or environmental risk factors pertur...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-30573 | biostudies-arrayexpress
ProteomicsHuman tRNA genes enable differential nonsense suppression in live cells and a model of frontotemporal dementia
Nonsense mutations generate premature termination codons (PTCs) that are responsible for 11% of human genetic disease alleles. Thus, nonsense suppressor tRNAs have broad therapeutic potential. Humans encode > 600 tRNA genes with many identical or similar copies of each tRNA. We hypothesized that tRN...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD056053 | Pride
Therapeutics Live-cell fluorescent reporters Frontotemporal dementia Trna Nonsense suppression Progranulin Protein synthesis 
ProteomicsProtein interactions of a novel tRNA-derived small RNA
Explore protein binding partners of novel tRNA (tRNA-Asp-GTC-3'tDR) in HEK293 cells via IP followed by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD052235 | Pride
Mass spectrometry Protein binding Trna Human Hek293 
GenomicsInduction of sarcomas by mutant IDH2
More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation ...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-50539 | biostudies-arrayexpress
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
UnknownPlasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer: the STAMPEDE Phase 3 Randomized Clinical Trial.
Not available
S-EPMC11869088 | biostudies-literature
UnknownWarfarin and aspirin in patients with heart failure and sinus rhythm.
Not available
S-EPMC3723382 | biostudies-literature
UnknownImpact of postoperative acute kidney injury in patients undergoing major gastrointestinal surgery on 1-year survival and renal outcomes: a national multicentre cohort study.
Not available
S-EPMC8759520 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
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