Sort   by:  
 Page size 
TranscriptomicsA Novel Model of Common TLR4- and Injury induced transcriptional themes in Human Leukocytes (supported by NIH grant GM34695)
Fifteen human volunteer subjects (18-40 years of age) and 5 Trauma patients were studied. One volunteer group (saline + LPS [n = 8]) received a 12 hour infusion a second volunteer group (cortisol + LPS [n = 7]) received a 12 hour infusion of cortisol (3 µg/kg/min). After 6 hours of saline or corti...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22278 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukocytes after an inflammatory stimulus (bacterial endotoxin) to identify significant functional modules perturbed in response to this stimulus using network analysis
Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize treatment regimens. However, extracting new biological insight from high-throughput genomic studies of human diseases is a challenge, limited by...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-3284 | biostudies-arrayexpress
TranscriptomicsA genomic storm in critically injured humans
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and show that the severe stress produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “ge...
ORGANISM(S): Homo sapiens 
2012-03-26 | E-GEOD-36809 | biostudies-arrayexpress
Sort   by:  
 Page size