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TranscriptomicsTranscriptional profiling of bulge stem cells
In adult skin, each hair follicle contains a reservoir of stem cells (the bulge), which can be mobilized to regenerate the new follicle with each hair cycle and to reepithelialize epidermis during wound repair. Here we report new methods that permit their clonal analyses and engraftment and demonstr...
ORGANISM(S): Mus musculus 
2012-10-19 | E-GEOD-41704 | biostudies-arrayexpress
GenomicsThe histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation
Here we show that T-box proteins team up with chromatin modifying enzymes to drive the expression of the key lineage regulator, Eomes during endodermal differentiation of embryonic stem (ES) cells. The Eomes locus is maintained in a transcriptionally poised configuration in ES cells. During early di...
ORGANISM(S): Mus musculus 
2013-04-18 | E-GEOD-44764 | biostudies-arrayexpress
ProteomicsThe mechanism of infochemicals induced colony formation and flocculation in the microalga Scenedesmus subspicatus
Daphnia infochemicals can induce defensive responses in microalgae Scenedesmus spp., including colony formation and flocculation. We investigated the phenomenon using a combination of microalgal biology, physiological ecology, and quantitative isobaric tagging (iTRAQ) proteomics. We have discovered ...
ORGANISM(S): Desmodesmus subspicatus 
2020-05-06 | PXD014153 | Pride
Daphnia infochemicals Scenedesmus Induced defences Colony formation itraq proteomics Flocculation Predation 
UnknownGranzyme B in peripheral blood mononuclear cells as a measure of cell-mediated immune response in paraneoplastic neurological syndromes and malignancy.
Not available
S-EPMC8053162 | biostudies-literature
TranscriptomicsEpigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms [methylation array]
Human pluripotent stem cells hold great potential for regenerative medicine, but existing cell types have imitations. Human embryonic stem cells derived from fertilized embryos (IVF-ESCs) are considered the “gold standard”, but are allogeneic to potential recipients. Autologous induced pluripotent s...
ORGANISM(S): Homo sapiens 
2014-07-08 | E-GEOD-53060 | biostudies-arrayexpress
TranscriptomicsEpigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms [RNA-Seq]
Human pluripotent stem cells hold great potential for regenerative medicine, but available cell types have important limitations. While embryonic stem cells derived from fertilized embryos (IVF-ESCs) are considered the "gold standard" of pluripotency, they are allogeneic to potential recip...
ORGANISM(S): Homo sapiens 
2014-07-08 | E-GEOD-53094 | biostudies-arrayexpress
TranscriptomicsDefining the role of oxygen tension in human neural progenitor fate
Hypoxia augments human embryonic stem cell self-renewal via hypoxia-inducible factor 2M-NM-1 (HIF2M-NM-1) activated OCT4 (POU5F1) transcription. Hypoxia also increases the efficiency of reprogramming differentiated cells to a pluripotent-like state. Combined, these findings suggest that low oxygen (...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-61842 | biostudies-arrayexpress
TranscriptomicsEpigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms [SNP array]
Human pluripotent stem cells hold great potential for regenerative medicine, but available cell types have important limitations. While embryonic stem cells derived from fertilized embryos (IVF-ESCs) are considered the "gold standard" of pluripotency, they are allogeneic to potential recip...
ORGANISM(S): Homo sapiens 
2014-07-08 | E-GEOD-53141 | biostudies-arrayexpress
TranscriptomicsEpigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-07-08 | E-GEOD-53096 | biostudies-arrayexpress
ProteomicsProtein cycling in the eastern tropical North Pacific oxygen deficient zone: a de novo-discovery peptidomic approach
Peptides and proteins were identified using a novel de novo-discovery approach in suspended and sinking organic particles from the eastern tropical North Pacific and in a culture of a dominant autotroph from the region, the cyanobacterium Prochlorococcus. De novo peptide sequencing, where the sequen...
ORGANISM(S): environmental samples <unclassified 
2022-01-10 | PXD023187 | Pride
Marine organic matter Eastern tropical north pacific Metaproteomics Oxygen deficient zones Protein and peptide cycling Particulate organic matter De novo peptide sequencing 
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