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TranscriptomicsModeling tumor subtypes in vivo using lineage restricted transgenic shRNA
Expression analysis from two genetically engineered mouse models of osteosarcoma determine the expression profile of mouse osteosarcoma Human osteosarcoma (OS) is comprised of three different subtypes: fibroblastic, chondroblastic and osteoblastic. We previously generated a mouse model of fibroblast...
ORGANISM(S): Mus musculus 
2013-03-28 | E-GEOD-38742 | biostudies-arrayexpress
MetabolomicsSerum lipidomic profile of cold-exposed Ucp1cre/12-LOX KO mice
Not available
ORGANISM(S): Mus musculus 
ST001213 | MetabolomicsWorkbench
MetabolomicsLipidomics in the serum of cold exposed mice treated with 12-LOX inhibitor LOXBlock-1
Not available
ORGANISM(S): Mus musculus 
ST001207 | MetabolomicsWorkbench
TranscriptomicsComparison of transcriptomes of LOX-1 KO and WT mice and effects of angiotensin 2
LOX KO and WT genotype comparison
ORGANISM(S): Mus musculus 
2010-12-17 | E-MTAB-473 | biostudies-arrayexpress
TranscriptomicsEffect of LOX-PP on the gene expression profile of the A673 cell line (Ewing sarcoma)
In this study we show that lysyl oxidase (LOX), an enzyme involved in maintaining structural integrity of the extracellular matrix, is expressed at low levels in Ewing sarcoma cells and primary tumors and is downregulated by the EWS/FLI1 oncoprotein characteristic of these tumors. Using a doxycyclin...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-46407 | biostudies-arrayexpress
GenomicsTransposon sequencing to identify random insertions of lox sites in Mycoplasma pneumoniae
This dataset was used to assess the random insertion by tranposases of lox sites in Mycoplasma pneumoniae. This is part of the protocol LoxTnSeq, a new methodology to generate and catalogue libraries of genome reduction mutants. LoxTnSeq combines random integration of Lox sites by transposon mutagen...
ORGANISM(S): Mycoplasma pneumoniae 
2021-08-18 | E-MTAB-9590 | biostudies-arrayexpress
TranscriptomicsExpression data from E11.5 mouse branchial arch 1 (BA1) - comparison between Ezh2lox/lox and Wnt1Cre Ezh2lox/lox embryos
Conditional ablation of Ezh2 in the neural crest lineage results in loss of the neural crest-derived mesenchymal derivatives. In this data sheet we determine gene expression analysis in Ezh2lox/lox and Wnt1Cre Ezh2lox/lox in E11.5 mouse BA1 cells. Conditional ablation of Ezh2 in the neural crest lin...
ORGANISM(S): Mus musculus 
2013-11-09 | E-GEOD-52220 | biostudies-arrayexpress
ProteomicsA highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
The assessment of global changes in fibrillar collagens and to the larger extent e.g., ECM induced upon inhibitor treatment has largely been lacking for the currently available LOX family inhibitors. We therefore undertook a quantitative pharmacodynamics approach to characterize the global alteratio...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-01 | PXD052642 | Pride
Lox inhibitor Collagen architecture Ros Lysyl oxidase Fak Tnbc chemoresistance 
TranscriptomicsCyldko
Effect of Cyld inactivation in liver. The Cyld gene was conditionally inactivated specifically in the liver by crossing mice carrying floxed exon 9 allele of Cyld with Alfp-Cre transgenic mice. Liver RNAs from Cyld lox/lox-AlfpCre mice were compared with RNAs prepared from the livers of wild type li...
ORGANISM(S): Mus musculus 
2012-02-01 | E-MEXP-3478 | biostudies-arrayexpress
ProteomicsA highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) data investigating changes in extracellular matrix/collagen architecture of mouse tumor tissue in response to LOX inhibition. Sample Key: Vehicle, Doxo (Chemotherapy drug), 6403 (LOX inhibitor), Combo (Doxo + LOX inhib...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-25 | PXD052657 | Pride
Lox inhibitor Mouse Lysyl oxidase Tnbc chemoresistance 
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