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MetabolomicsA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe a...
2024-10-25 | MTBLS10416 | MetaboLights
ProteomicsLPS Tolerance inhibits cellular respiration and induces global changes in the secretome
Inflammatory response plays an essential role in the resolution of infections. However, inflammation can be detrimental to the organism and cause irreparable damage, for example during sepsis, when a “cytokine storm” can lead to multiple organ failure and often ends in death. One of the strongest tr...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021925 | Pride
Macrophages Raw 264.7 Secretome Lps tolerance 
TranscriptomicsTranscriptional profiling of macrophage plasticity following recovery from Lipopolysaccharide (LPS) tolerance
To investigate the plasticity of Lipolysaccharide (LPS) tolerance, we employed microarray profiling to analyse the gene expression profile in macrophage. Four macrophage populations were induced; Untreated macrophages (Control group), Acute response to LPS (LPS activation group), LPS tolerance (T – ...
ORGANISM(S): Mus musculus 
2013-12-06 | E-GEOD-47783 | biostudies-arrayexpress
TranscriptomicsCompare RNA profile between LPS+CPN and LPS+CPN+GGOH treated peritoneal macrophages
To find out genes regulated by geranylgeraniol (GGOH) treatment in peritoneal macrophage, we compared gene expression of cells treated with 200ng ml LPS and 250 micromolar compactin versus 200ng ml LPS, 250 micromolar compactin and 100micromolar GGOH. To find out upregulated or downregulated genes r...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-48646 | biostudies-arrayexpress
TranscriptomicsNFAT-mediated gene expression response to LPS in murine dendritic cells and macrophages
This SuperSeries is composed of the following subset Series: GSE15718: Gene expression in dendritic cells stimulated with LPS in conditions allowing or inhibiting NFAT activation GSE15720: Apoptosis genes specifically modulated by NFAT in LPS-activated dendritic cells GSE15721: Gene expression in ma...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15759 | biostudies-arrayexpress
TranscriptomicsGene expression in macrophages stimulated with LPS in conditions allowing or inhibiting NFAT activation
Macrophages and dendritic cells (DCs) differently contribute to the generation of coordinated immune system responses against infectious agents. They interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorg...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-15721 | biostudies-arrayexpress
ProteomicsLPS upregulates palmitoylated enzymes of the phosphatidylinositol cycle. An insight from proteomic studies.
The studies aim at revealing changes of the level of fatty-acylated proteins induced by LPS in RAW264 macrophage-like cells
ORGANISM(S): Mus musculus (Mouse) 
2017-12-15 | PXD007918 | Pride
Proteomic Lps S-palmitoylation. mass spectrometry 
TranscriptomicsGene expression in dendritic cells stimulated with LPS in conditions allowing or inhibiting NFAT activation
Interleukin-2 (IL-2) is one of the molecules produced by mouse dendritic cells (DCs) after stimulation by Toll like receptor (TLR) agonists. By analogy with the events following T-cell receptor (TCR) engagement leading to IL-2 production we have observed that DC stimulation with lipopolysaccharide (...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-15718 | biostudies-arrayexpress
TranscriptomicsLPS-induced gene expression in mouse small intestinal epithelial cells
Intestinal epithelial cells express the lipopolysaccharide (LPS) receptor Toll-like receptor (TLR4) and are responsive to LPS stimulation. Following LPS exposure, epithelial cells, similar to myeloid cells such as macrophages, acquire a state of tolerance. Innate immune tolerance is characterized by...
ORGANISM(S): Mus musculus 
2010-08-29 | E-GEOD-23755 | biostudies-arrayexpress
TranscriptomicsLPS tolerance in macrophages
Among the multiple mechanisms that control the intensity and duration of macrophage activation, the development of a state of refractoriness to a second stimulation in cells treated with LPS has long been recognized. Release of inhibitory cytokines and alterations in intracellular signaling pathways...
ORGANISM(S): Mus musculus 
2007-08-10 | GSE8621 | GEO
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