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TranscriptomicsOncogenic Functions of the Transcription Factor LSF
Overexpression of LSF in less aggressive hepatocellular carcinoma (HCC) cells resulted in highly aggressive, angiogenic and multi-organ metastatic tumors while inhibition of LSF significantly abrogated growth and metastasis of highly aggressive HCC cells in nude mice. We used microarrays to identify...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-19815 | biostudies-arrayexpress
GenomicsLSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells
LSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells
PRJNA548009 | ENA
GenomicsLSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells
The oncogene LSF has been proposed as a novel target with therapeutic potential for multiple cancers. LSF overexpression correlates with poor prognosis for both liver and colorectal cancers, for which there are currently limited therapeutic treatment options. In particular, molecularly targeted ther...
ORGANISM(S): Homo sapiens 
2019-06-10 | GSE132419 | GEO
MetabolomicsMulti-Omics profiling reveals immunometabolic adaptations underlying disease resilience in indigenous Lueyang Silky Fowl compared to White Leghorns
Sustainable avian production demands genetic strategies beyond vaccines to enhance disease resilience, particularly in indigenous breeds like Lueyang Silky Fowl (LSF), which show superior resistance compared to commercial White Leghorn chickens (WLC) but lack molecular characterization. We hypothesi...
2026-05-27 | MTBLS14590 | MetaboLights
TranscriptomicsOncogenic Functions of the Transcription Factor LSF
Overexpression of LSF in less aggressive hepatocellular carcinoma (HCC) cells resulted in highly aggressive, angiogenic and multi-organ metastatic tumors while inhibition of LSF significantly abrogated growth and metastasis of highly aggressive HCC cells in nude mice. We used microarrays to identify...
ORGANISM(S): Homo sapiens 
2010-04-06 | GSE19815 | GEO
ProteomicsThe Anti-cancer Factor Quinolinone Inhibitors Disrupt Spindles and the Interactions between LSF and Microtubule-associated Proteins
Identification of mitotic BioLSF-interacting proteins whose association is sensitive to Factor Quinolinone Inhibitor 1 (FQI1): The dataset is comprised of two independent experimental replicates, with each biological replicate consisting of runs of 4 samples. For each set, the four protein samples w...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD024149 | Pride
Lsf Fqi1 Mitosis Tfcp2 Protein-protein interactions 
UnknownAntiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma.
Not available
S-EPMC3311344 | biostudies-literature
UnknownTranscription factor LSF (TFCP2) inhibits melanoma growth.
Not available
S-EPMC4823042 | biostudies-literature
GenomicsHomo sapiens
Oncogenic Functions of the Transcription Factor LSF
PRJNA122087 | ENA
UnknownLate SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9).
Not available
S-EPMC3270996 | biostudies-literature
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