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UnknownTranscription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression.
Not available
S-EPMC5347793 | biostudies-literature
ProteomicsThe Anti-cancer Factor Quinolinone Inhibitors Disrupt Spindles and the Interactions between LSF and Microtubule-associated Proteins
Identification of mitotic BioLSF-interacting proteins whose association is sensitive to Factor Quinolinone Inhibitor 1 (FQI1): The dataset is comprised of two independent experimental replicates, with each biological replicate consisting of runs of 4 samples. For each set, the four protein samples w...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD024149 | Pride
Lsf Fqi1 Mitosis Tfcp2 Protein-protein interactions 
UnknownTargeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence.
Not available
S-EPMC7296649 | biostudies-literature
UnknownFactor quinolinone inhibitors alter cell morphology and motility by destabilizing interphase microtubules.
Not available
S-EPMC8651680 | biostudies-literature
UnknownFactor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins.
Not available
S-EPMC9200292 | biostudies-literature
UnknownAntiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma.
Not available
S-EPMC3311344 | biostudies-literature
UnknownSmall molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.
Not available
S-EPMC4694900 | biostudies-literature
ProteomicsMicrotubules methylation LC-MSMS
Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood. Post-translational modifications of tubulin are proposed to regulate...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2020-02-28 | PXD014257 | Pride
Human Monomethylation Tubulin 
GenomicsLSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells
The oncogene LSF has been proposed as a novel target with therapeutic potential for multiple cancers. LSF overexpression correlates with poor prognosis for both liver and colorectal cancers, for which there are currently limited therapeutic treatment options. In particular, molecularly targeted ther...
ORGANISM(S): Homo sapiens 
2019-06-10 | GSE132419 | GEO
UnknownThe microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates α-tubulin.
Not available
S-EPMC7135998 | biostudies-literature
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