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ProteomicsMS/MS analysis of Ub-conjugated UbcH7 ubiquitination sites
By conducting the ubiquitin-conjugation assay for UbcH7, we found that PknG was able to promote the loading of Ub onto UbcH7, which is indicated by a molecular weight shift in SDS–PAGE. The classic Ub conjugation of E2s requires the E1 to form a thiol-ester bond between its active Cys and the C-term...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD020982 | Pride
Ms Unconventional isopeptidase activitys 
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [iBDMDs]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074476 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
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