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TranscriptomicsExpression analysis of human melanoma short-term culture WM451-Lu harvested after lentiviral infection with a GFP (control) or SETDB1 (experimental) viral vector
Investigation of expression differences induced by expression of the histone methyltransferase SETDB1 in human melanoma short-term culture WM451-Lu. A six-chip study using total RNA prepared from WM451-Lu melanoma short-term cultures infected with either a lentivirus encoding GFP (control) or SETDB1...
ORGANISM(S): Homo sapiens 
2011-01-07 | E-GEOD-26371 | biostudies-arrayexpress
Unknown177 Lu-rhPSMA-10.1 Induces Tumor Response in a Patient With mCRPC After PSMA-Directed Radioligand Therapy With 177 Lu-PSMA-I&T.
Not available
S-EPMC9988218 | biostudies-literature
TranscriptomicsmicroRNA Profiling in Wilms Tumors and Kidney Tissues
The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. The expression levels of microRNAs were profiled in 20 human Wilms tumor samples (WT), 3 human normal adult kidney samples (AK) and 5 human fetal kidney samples (FK) using a Luminex bea...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-50505 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of subcutaneous patient-derived neuroblastoma xenografts (LU-NB-3R): Comparison of BAY390, A967079, and vehicle controls
Neuroblastoma (NB) is a pediatric cancer characterized by significant heterogeneity and poor prognosis, particularly in high-risk cases with MYCN amplification. Understanding the molecular response of neuroblastoma to different treatments can provide valuable insights into potential therapeutic stra...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-15002 | biostudies-arrayexpress
Transcriptomics3' sequencing following PRMT inhibition in RPE-1 cells and CDK4/CDK6 inhibition in LU-99 cells
Numerous RNA-binding proteins are arginine methylated and inhibition of arginine methylation triggers changes in alternative polyadenylation in cancer cells. Therefore we aimed to investigate whether this phenotype was also triggered in an untransformed cell line - RPE-1. RPE-1 cells were treated wi...
ORGANISM(S): Homo sapiens 
2026-10-19 | E-MTAB-17463 | biostudies-arrayexpress
TranscriptomicsRNA-seq of tumor organoids from patient-derived xenograft (PDX, LU-NB-2) of high-risk, MYCN-amplified neuroblastoma treated with prochlorperazine (PCZ), pitavastatin (PIT), the combination of both drugs, and untreated controls.
Neuroblastoma (NB) is a pediatric cancer characterized by significant heterogeneity and poor prognosis, especially in high-risk cases with MYCN amplification. Understanding the molecular response of neuroblastoma to different treatments can provide insights into potential therapeutic strategies. The...
2025-05-25 | E-MTAB-14846 | biostudies-arrayexpress
TranscriptomicsRNA-seq of subcutaneous patient-derived neuroblastoma xenografts (LU-NB-1) - Comparison of Prochlorperazine + Pitavastatin (PCZ+PIT) combination alone to one combined with standard-of-care COJEC protocol (PCZ+PIT+COJEC)
Neuroblastoma (NB) is a pediatric cancer characterized by significant heterogeneity and poor prognosis, specially in high-risk cases with MYCN amplification. Understanding the molecular response of neuroblastoma to different treatments can provide insights into potential therapeutic strategies. The ...
ORGANISM(S): Homo sapiens 
2025-07-30 | E-MTAB-14902 | biostudies-arrayexpress
Transcriptomics3' sequencing following arginine methylation inhibition +/- FLAG-PCF11, FLAG-CSTF2 or FLAG-GFP in LU-99
Cleavage and polyadenylation factors PCF11 and CSTF2 are arginine methylation substrates. Therefore we aimed to study how the alternative polyadenylation changes caused by arginine methylation inhibition are affected by overexpression of either PCF11 or CSTF2. We generated LU-99 cell lines expressin...
ORGANISM(S): Homo sapiens 
2026-10-19 | E-MTAB-17496 | biostudies-arrayexpress
MetabolomicsIntegrated microbiome-metabolome-genome axis data of Laiwu and Lulai pigs
Excessive fat deposition can trigger metabolic diseases, and it is crucial to identify factors that can break the link between fat deposition and metabolic diseases. Healthy obese Laiwu pigs (LW) are high in fat content but resistant to metabolic diseases. In this study, we compared the fecal microb...
2023-04-20 | MTBLS3977 | MetaboLights
Transcriptomics3' sequencing following 96hrs ADMAi, SDMAi or ADMAi+SDMAi in LU-99 cells
Numerous RNA-binding proteins involved in alternative polyadenylation are arginine methylation substrates. There are two forms of dimethylation - asymmetric dimethylation (ADMA) and symmetric dimethylation (SDMA). We aimed to study how alternative polyadenylation is impacted by preventing arginine m...
ORGANISM(S): Homo sapiens 
2026-10-19 | E-MTAB-14928 | biostudies-arrayexpress
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