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TranscriptomicsEvx1as and EVX1 knockouts by CRISPR
We report that long noncoding RNAs contribute to transcription and developmental process. Thousands of lncRNAs have been identified in the whole genome, and tend to located closely to protein-coding genes. To study position relationship between lncRNA and protein-coding genes, we classified all of l...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-70419 | biostudies-arrayexpress
Transcriptomicscis regulated role of lncRNA in transcriptional or developmental process (ChIRP-Seq)
We report that long noncoding RNAs contribute to transcription and developmental process. Thousands of lncRNAs have been identified in the whole genome, and tend to located closely to protein-coding genes. To study position relationship between lncRNA and protein-coding genes, we classified all of l...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-79541 | biostudies-arrayexpress
MetabolomicsOsh2 mediates Candida resistance to miltefosine by regulating zymosterol transport
Miltefosine has been identified for its antifungal properties, yet the mechanisms underlying its action and the development of resistance remain unclear. In this study, we induced drug resistance in various Candida species through concentration gradient exposure, successfully obtaining a miltefosine...
2025-07-03 | MTBLS12270 | MetaboLights
TranscriptomicsOpposing roles for the lncRNA Haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation
Long noncoding RNAs (lncRNAs) have been implicated in controlling various aspects of embryonic stem cell (ESC) biology, although the functions of specific lncRNAs, and the molecular mechanisms through which they act, remain unclear. Here, we demonstrate discrete and opposing roles for the lncRNA tra...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-58514 | biostudies-arrayexpress
UnknownQingxie Fuzheng granules attenuate cancer cachexia by restoring gut microbiota homeostasis and suppressing IL-6/NF-κB signaling in colorectal adenocarcinoma.
Not available
S-EPMC12398093 | biostudies-literature
Proteomics2022-0222-SK cell line infected by ZIKV（MR766,PRVABC.59)-1044
In this project, mass spectrometer Q-Exactive HF X was used. Total number of 43898 spectra were obtained from the sample group SK_mock. After identification by search engine, 6733 spectra were matched, 1094 proteins and 5074 peptides were identified.Total number of 46943 spectra were obtained from t...
ORGANISM(S): Homo Sapiens 
2024-03-25 | PXD050964 |
ProteomicsTemporal proteomics characterization of COVID-19 patient sera
We enrolled 37 SARS-CoV-2 positive patients including 17 short course (SC) COVID-19 patients (twice viral RNA detection negative over 24 hrs) and 20 COVID-19 long course (LC) COVID-19 patients. We also included 35 SARS-CoV-2 negative patients as control group. We collected 224 inactive serum samples...
ORGANISM(S): Homo Sapiens 
2022-07-26 | PXD035471 |
ProteomicsIdentification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly
The stained gel bands are washed three times with ddH2O, followed by the addition of 150μL of destaining solution to remove the stain. After four rounds of water washing, the gel bands are washed twice with 300μL each of 25mM ammonium bicarbonate, 50% acetonitrile, and 100% acetonitrile, respectivel...
ORGANISM(S): Homo Sapiens 
2024-08-14 | PXD054904 |
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation
dNxf2 directly interacts with dNxf1 to compete with its binding to NPC
ORGANISM(S): Drosophila Melanogaster 
2019-08-01 | PXD014884 |
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation, Panx-IP-MS
The repression of transposons by the Piwi-interacting RNA (piRNA) pathway is essential to protect animal germ cells. In Drosophila ovaries, Panoramix (Panx) enforces transcriptional silencing by binding to the target-engaged Piwi-piRNA complex, although the precise mechanisms by which this occurs re...
ORGANISM(S): Drosophila Melanogaster 
2019-08-06 | PXD014926 |
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