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MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-04 | PXD072640 |
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-08 | PXD072904 |
ProteomicsAge-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
To determine the molecular landscape of large intestinal aging, we collected 104 pieces of fresh large intestinal tissue from 26 Macaca fascicularis and performed age-, location-, and sex-resolved multi-omics analyses, including transcriptomics, proteomics, phosphoproteomics and metabolomics.
ORGANISM(S): Macaca Fascicularis Fascicularis 
2024-01-18 | PXD039361 |
ProteomicsProteomics data of colorectal cancer
Paired tumor and distant normal tissues from a cohort of 104 colon cancer patients were collected at West China Hospital and snap-frozen in liquid nitrogen. The informed consent forms were signed by the participants or their family members.
ORGANISM(S): Homo Sapiens 
2023-01-11 | PXD039360 |
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