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ProteomicsMechanism of TP53 and RB1 inactivation-induced neuroendocrine phenotype transformation in TKI-resistant lung adenocarcinoma
In order to study the mechanism of co-inactivation of RB1 and TP53 in the transformation of lung adenocarcinoma to small cell lung cancer, we established the NCI-H1975 cell line with RB1 knockdown.NCI-H1975 cells were cultured and infected with lentivirus expressing RB1-shRNA (n=3) or pLKO.1-shRNA (...
ORGANISM(S): Homo sapiens (Human) 
2023-08-20 | PXD042073 | Pride
Transformation Sclc Notch Tki therapy resistance Luad 
UnknownCNPase, a 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production.
Not available
S-EPMC8509266 | biostudies-literature
ProteomicsInteractome of FLAG-STING in HCT116 cell line with or without P. gingivalis infection
The project aims to identify STING interactome that affected by P. gingivalis infection in HCT116 cells.
ORGANISM(S): Homo Sapiens 
2025-09-18 | PXD068516 |
ProteomicsProteomics profile of large extracellular vesicles derived from P. gingivalis–infected HCT116 cells
HCT116 cells were treated with/without P. gingivalis for 48h, then the large extracellular vesicles (lEV) were isolated via a series of differential centrifugation steps. then the purified lEVs were used for label free quantitative proteomics analysis. Three biological replicates are prepared for ea...
ORGANISM(S): Homo Sapiens 
2025-01-17 | PXD059913 |
ProteomicsLC-MS/MS identified the TRIM16-binding proteins
Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD). To date, effective treatments for VC are still lacking since the underlying mechanisms remains elusive. RNA-sequencing analysis revealed that the E3 ubiquitin ligase Tripartite motif 16 (TRIM16) may be a k...
ORGANISM(S): Homo Sapiens 
2024-03-27 | PXD051036 |
ProteomicsShiga toxin 2a induces mitochondrial damage, mitophagy and apoptosis via the interaction of Tom20 in Caco-2 cells
Shiga toxin type 2 (Stx2) is the main virulence factor produced by Stx-producing Escherichia coli (STEC) responsible for hemorrhagic colitis and the life-threatening sequela hemolytic uremic syndrome.
ORGANISM(S): Homo Sapiens 
2022-11-21 | PXD038256 |
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