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ProteomicsA Photocrosslinking Probe to Capture the Substrates of Caseinolytic Protease P
Protein homeostasis in bacteria is regulated by proteases such as the tetradecameric caseinolytic protease P (ClpP). Although substrates of ClpP have been successfully deciphered in genetically engineered cells, methods which directly trap processed proteins within native cells remain elusive. Here,...
ORGANISM(S): Staphylococcus aureus 
2024-10-04 | PXD047274 | Pride
S. aureus Substrates 
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
TranscriptomicsHighly Pathogenic Avian Influenza Viruses Avoid Effective Inflammatory Response of Human Macrophages
Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1). To our surprise a genome-wide comparative systems biology approach revealed that in contrast PR8 infections with HPAIV H5N1 and FPV result in a reduced immune response of human macrophages contradicting a ...
ORGANISM(S): Homo sapiens 
2012-05-28 | E-GEOD-27702 | biostudies-arrayexpress
UnknownChanges in ventilation distribution during general anesthesia measured with EIT in mechanically ventilated small children.
Not available
S-EPMC10091533 | biostudies-literature
TranscriptomicsTranscription profiling of HUVEC infected with Influenza virus
To delineate specific patterns of signaling networks activated by H5N1 we used a comparative systems biology approach analyzing gene expression in endothelial cells infected with three different human and avian influenza strains of high and low pathogenicity. HUVECs were infected with either PR8, F...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-13637 | biostudies-arrayexpress
UnknownFine-mapping and selective sweep analysis of QTL for cold tolerance in Drosophila melanogaster.
Not available
S-EPMC4169155 | biostudies-literature
UnknownInferring the population structure and demography of Drosophila ananassae from multilocus data.
Not available
S-EPMC1448708 | biostudies-literature
UnknownThe de Novo Reference Genome and Transcriptome Assemblies of the Wild Tomato Species Solanum chilense Highlights Birth and Death of NLR Genes Between Tomato Species.
Not available
S-EPMC6893187 | biostudies-literature
UnknownSurvival Rate and Transcriptional Response upon Infection with the Generalist Parasite Beauveria bassiana in a World-Wide Sample of Drosophila melanogaster.
Not available
S-EPMC4495925 | biostudies-literature
UnknownSubcutaneous vitamin B12 administration using a portable infusion pump in cobalamin-related remethylation disorders: a gentle and easy to use alternative to intramuscular injections.
Not available
S-EPMC8114704 | biostudies-literature
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