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ProteomicsMitochondrial damage drives T-cell immunometabolic paralysis after major surgery
Cytotoxic T cell (CTL) dysfunction is a key feature of immune paralysis following major surgery, significantly increasing the risk of severe nosocomial infections and contributing to elevated mortality in critically ill patients. The pathomechanisms of CTL dysfunction remain unclear. We report that ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-04 | MSV000097035 | MassIVE
UnknownEffect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis.
Not available
S-EPMC4667723 | biostudies-literature
UnknownMitochondrial damage drives T-cell immunometabolic paralysis after major surgery
Not available
S-SCDT-10_1038-S44321-025-00324-1 | biostudies-other
TranscriptomicsTranscription profiling by array of Arabidopsis after infection with different strains of Agrobacterium tumefaciens
This study focuses on responses of the host plant to infection with Agrobacterium tumefaciens. Genome wide changes in gene expression were integrated with the alterations in metabolite levels three hours after inoculation of agrobacteria. Plants were infected with the virulent strain C58, harboring ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-02 | E-GEOD-13929 | biostudies-arrayexpress
UnknownLegionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase.
Not available
S-EPMC5126622 | biostudies-literature
ProteomicsTransforming chemical proteomics into high-throughput method using SP2E workflow.
Protein post-translational modifications (PTMs) play a critical role in regulation of protein catalytic activity, localization and protein-protein interactions. An attachment of PTMs onto proteins significantly diversify their structure and function resulting in so called proteoforms. However, the s...
ORGANISM(S): Homo sapiens (Human) 
2022-07-04 | PXD033644 | Pride
Method development Ampylation 
ProteomicsAMPylation profiling during neuronal differentiation reveals extensive variation on lysosomal proteins
Protein AMPylation is a prevalent posttranslational modification with an emerging role in neurodevelopment and neurodegeneration. Although in metazoans the two highly conserved protein AMP-transferases together with diverse group of AMPylated proteins have been identified using chemical proteomics a...
ORGANISM(S): Homo sapiens (Human) 
2021-12-01 | PXD023873 | Pride
Lysosome Ampylation 
UnknownIdentification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study.
Not available
S-EPMC3595425 | biostudies-literature
TranscriptomicsRNA-seq experiment to investigate the impact of sulforaphane metabolism in HepG2 cells. Cells with NRF2 knockdown treated with sulforaphane were compared to untreated cells with NRF2 knock-down. Similarly, wild type cells treated with sulforaphane were compared to untreated cells.
This study aims to assess whether genes involved in central metabolism induced by Sulforaphane, SF, are mediated through the transcription factor NRF2. A time course RNA-seq experiment was performed, where RNA is extracted after 3, 9, and 24 hours SF treatment. This experiment tests the following hy...
ORGANISM(S): Homo sapiens 
2024-03-30 | E-MTAB-12858 | biostudies-arrayexpress
TranscriptomicsDetecting lung tumors from circulating microRNA profiles
We aimed to determine if lung cancer detection can be improved by circulating miRNAs as biomarkers. To this end, we collected blood of over 3000 individuals using PAXgene blood tubes. The individuals were diagnosed with lung cancer (LCa), a non-tumor lung disease (NTLD), another disease (OD) or were...
ORGANISM(S): Homo sapiens 
2020-05-19 | E-MTAB-8026 | biostudies-arrayexpress
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