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ProteomicsNeuronal differentiation of LUHMES cells is accompanied by substantial changes of the proteome
To study mechanisms of neurodegenerative diseases, neuronal cell lines are important model systems and are often differentiated into postmitotic neuron-like cells to resemble more closely primary neurons obtained from brains. One such cell line is the Lund Human Mesencephalic (LUHMES) cell line whic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-09-24 | PXD020044 | Pride
Luhmes cells Dopaminergic neuron Murine midbrain neurons Parkinson’s disease 
ProteomicsTranscriptome and proteome analysis in LUHMES cells overexpressing alpha-synculein
LUHMES cells share many characteritics with human dopamingeric neurons in the substantia nigra, the cells whose demise is responsible for the motor symptoms in Parkinson’s disease (PD). LUHMES cells can therefore be used bona fide as a model to study pathophysiological processes involved in PD. Prev...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD028322 | Pride
Snca Parkinson’s disease (pd) Luhmes cells Alpha-synculein Neurodegenerative diseases Proteome Transcriptome 
TranscriptomicsRNA-seq of CSMD1 enhancer CRISPRi in LUHMES cells and differentiated neurons
we performed lentiviral CRISPR interference (CRISPRi) by recruiting dCas9 fused with the KRAB domain to the CSMD1 enhancer (fam3) in the neuronal precursor cell line – Lund human mesencephalic (LUHMES). Given that the expression of CSMD1 was not detectable in LUHMES cells we differentiated these cel...
ORGANISM(S): Homo sapiens 
2022-06-30 | E-MTAB-8027 | biostudies-arrayexpress
GenomicsTranscriptome and proteome analysis in LUHMES cells overexpressing alpha-synuclein
Transcriptome and proteome analysis in LUHMES cells overexpressing alpha-synuclein
PRJNA790940 | ENA
ProteomicsCharacterization of Non-histone Lysine Methylation Across Neuronal Differentiation of LUHMES
Over one-third of human lysine methyltransferases (KMTs) and lysine demethylases (KDMs), the enzymes responsible for adding or removing methylation on lysine residues within proteins, are linked to neurodevelopmental disorders (NDDs). Consequently, several studies have explored the roles of specific...
ORGANISM(S): Homo sapiens (Human) 
2026-10-02 | PXD069591 | Pride
Neuronal differentiation Luhmes Lysine methylation 
TranscriptomicsCapture Hi-C (HiCap) experiments performed on LUHMES cell line differentiated in three (D3) and six days (D6). We fragmented the genome using DpnII. HiCap experiments at each time point (D1, D3 and D6) are performed in two replicates
LUHMES cells are non-tumorigenic model of human dopaminergic neurons. Their physiology and phenotypic changes upon differentiation can provide clues into the pathology of neurological diseases such as dyslexia, autism, schizophrenia.
ORGANISM(S): Homo sapiens 
2024-01-14 | E-MTAB-13665 | biostudies-arrayexpress
GenomicsRNA-seq of CSMD1 enhancer CRISPRi in LUHMES cells and differentiated neurons
RNA-seq of CSMD1 enhancer CRISPRi in LUHMES cells and differentiated neurons
PRJEB32901 | ENA
TranscriptomicsTranscriptome and proteome analysis in LUHMES cells overexpressing alpha-synuclein
Differential transcriptome analysis in LUHMES cells overexpressing human wild-type alpha-synuclein or GFP
ORGANISM(S): Homo sapiens 
2022-03-31 | GSE191302 | GEO
GenomicsSystematic characterization of LUHMES cell-based Parkinson’s disease models reveals potential novel drug targets.
Systematic characterization of LUHMES cell-based Parkinson’s disease models reveals potential novel drug targets.
PRJNA1215333 | ENA
GenomicsCharacteriration of mitochondrial stress response in Luhmes-derived dopaminergic neurons Comparative expression profile using RNAseq after 8 hours of Antimycin + Oligomycin treatment in differentiated Luhmes cells
Characteriration of mitochondrial stress response in Luhmes-derived dopaminergic neurons Comparative expression profile using RNAseq after 8 hours of Antimycin + Oligomycin treatment in differentiated Luhmes cells
PRJNA1135932 | ENA
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