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ProteomicsMapping Protein Targets of Bioactive Small Molecules using Lipid-Based Chemical Proteomics
Lipids play critical roles in cell biology, often through direct interactions with proteins. We recently described the use of photoreactive lipid probes combined with quantitative mass spectrometry to globally map lipid-protein interactions, and the effects of drugs on these interactions, in cells. ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-26 | PXD007570 | Pride
Hek293t Neuro2a Orbitrap velos Chemoproteomics Lipid probes 
ProteomicsAIG1 and ADTRP are endogenous FAHFA hydrolases
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic activities. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, we find that androgen- induced gene 1 (AIG1) and andr...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-09 | PXD017539 | Pride
Threonine hydrolase Metabolism Adtrp Lipid Enzyme inhibitor Fahfa Aig1 Diabetes 
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