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ProteomicsAIG1 and ADTRP are endogenous FAHFA hydrolases
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic activities. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, we find that androgen- induced gene 1 (AIG1) and andr...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-09 | PXD017539 | Pride
Threonine hydrolase Metabolism Adtrp Lipid Enzyme inhibitor Fahfa Aig1 Diabetes 
GenomicsInflammation causes insulin resistance via IRF3-mediated reduction in FAHFA levels
Inflammation causes insulin resistance via IRF3-mediated reduction in FAHFA levels
PRJNA878829 | ENA
ProteomicsInflammation causes insulin resistance via IRF3-mediated reduction in FAHFA levels
Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through induction of the endogenous FAHFA hydrolase androgen induced gene 1...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-14 | PXD047864 | Pride
Mouse Irf3 Aig1 Inflammation Adipocytes Glucose metabolism High-fat diet Fahfa 
UnknownArtifactual FA dimers mimic FAHFA signals in untargeted metabolomics pipelines.
Not available
S-EPMC9034316 | biostudies-literature
UnknownIn-Silico-Generated Library for Sensitive Detection of 2-Dimethylaminoethylamine Derivatized FAHFA Lipids Using High-Resolution Tandem Mass Spectrometry.
Not available
S-EPMC8168918 | biostudies-literature
TranscriptomicsInflammation causes insulin resistance via IRF3-mediated reduction in FAHFA levels
Obesity-induced inflammation metabolic dysfunction, but the mechanisms remain elusive. Here we showed that the innate immune factor IRF3 is a direct transcriptional regulator of glucose homeostasis through induction of endogenous FAHFA hydrolase Aig1 in adipocytes. Adipocyte-specific knockout IRF3 p...
ORGANISM(S): Mus musculus 
2024-02-09 | GSE213048 | GEO
UnknownATGL-catalyzed biosynthesis mediates the upregulation of fatty acid hydroxy fatty acids (FAHFA) levels in white adipose tissue with fasting.
Not available
S-EPMC12934275 | biostudies-literature
UnknownFaster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements.
Not available
S-EPMC5962352 | biostudies-literature
UnknownInflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.
Not available
S-EPMC11139994 | biostudies-literature
TranscriptomicsFatty Acid Esters of Hydroxy Fatty Acids (FAHFA) Derivatives as Dual Modulators of Lipid Metabolism and Gut Microbiome in Obesity
Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs), endogenous lipids with anti-inflammatory and metabolic benefits, face challenges in clinical translation due to instability and high synthesis costs. This study introduces a scalable synthetic platform to engineer novel FAHFA derivatives with enhanc...
ORGANISM(S): Mus musculus 
2026-06-18 | GSE296368 | GEO
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