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ProteomicsAIG1 and ADTRP are endogenous FAHFA hydrolases
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic activities. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, we find that androgen- induced gene 1 (AIG1) and andr...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-09 | PXD017539 | Pride
Threonine hydrolase Metabolism Adtrp Lipid Enzyme inhibitor Fahfa Aig1 Diabetes 
UnknownAIG1 protects against doxorubicin-induced cardiomyocyte ferroptosis and cardiotoxicity by promoting ubiquitination-mediated p53 degradation.
Not available
S-EPMC12036874 | biostudies-literature
UnknownAIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.
Not available
S-EPMC4837090 | biostudies-literature
UnknownAIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
Not available
S-EPMC7196635 | biostudies-literature
ProteomicsInflammation causes insulin resistance via IRF3-mediated reduction in FAHFA levels
Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through induction of the endogenous FAHFA hydrolase androgen induced gene 1...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-14 | PXD047864 | Pride
Mouse Irf3 Aig1 Inflammation Adipocytes Glucose metabolism High-fat diet Fahfa 
UnknownAIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica.
Not available
S-EPMC5884625 | biostudies-literature
TranscriptomicsIdentification of mRNAs Regulated in Response to Transcriptional Activation of the Arabidopsis Abscisic Acid Insensitive Growth 1 (AIG1) Transcription Factor cDNA
Liquid grown, seven day old wild type Arabidopsis seedlings and seedlings carrying a cDNA encoding the Abscisic Acid Insensitive Growth (AIG1) gene under the control of an estrogen inducible promoter were treated with estrogen for 0, 60 and 120 minutes at which point seedlings were flash frozen and ...
ORGANISM(S): Arabidopsis thaliana 
2016-06-22 | E-GEOD-70100 | biostudies-arrayexpress
UnknownEvolution of Plant AIG1-like Proteins: Different Modes of Sequence Divergence and Their Contributions to Functional Diversification.
Not available
S-EPMC12845241 | biostudies-literature
UnknownAttenuation of In Vitro and In Vivo Virulence Is Associated with Repression of Gene Expression of AIG1 Gene in Entamoeba histolytica.
Not available
S-EPMC10051847 | biostudies-literature
TranscriptomicsInflammation causes insulin resistance via IRF3-mediated reduction in FAHFA levels
Obesity-induced inflammation metabolic dysfunction, but the mechanisms remain elusive. Here we showed that the innate immune factor IRF3 is a direct transcriptional regulator of glucose homeostasis through induction of endogenous FAHFA hydrolase Aig1 in adipocytes. Adipocyte-specific knockout IRF3 p...
ORGANISM(S): Mus musculus 
2024-02-09 | GSE213048 | GEO
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