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MetabolomicsLuminal metabolome profiles ofUC-HMA mice transplanted with a healthy human-derived fecal microbiota (FMT).
Not available
ORGANISM(S): Mus musculus 
ST001300 | MetabolomicsWorkbench
TranscriptomicsMicroarray expression profiling study of Runx1-null and wild type luminal mammary epithelial cells
RUNX1 encodes a RUNX family transcription factor (TF) and was recently identified as a novel mutated gene in human luminal breast cancers. We found that Runx1 is expressed in all subpopulations of murine mammary epithelial cells (MECs) except the secretory alveolar luminal cells. Conditional knockou...
ORGANISM(S): Mus musculus 
2014-11-26 | E-GEOD-47375 | biostudies-arrayexpress
GenomicsZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification ...
EGAS00000000082 | EGA
TranscriptomicsLoss of the retinoblastoma tumor suppressor is a common event in Basal-like and Luminal B breast carcinomas
Breast cancers can be classified using whole genome expression into distinct subtypes that show differences in patient prognosis. One of these groups, the basal-like carcinomas, are poorly differentiated, highly metastatic, and genomically unstable. These tumors also contain specific genetic alter...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-10884 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of purified populations of normal human breast luminal and myoepithelial cells
Purified populations of normal human breast luminal and myoepithelial cells were compared with cDNA microarray analysis.
ORGANISM(S): Homo sapiens 
2004-05-04 | E-MEXP-36 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomic analyses of triple negative and luminal A breast ductal carcinoma in situ
This experiment includes GeoMx spatial transcriptomic analyses of FFPE tissue from breast ductal carcinoma in situ lesions from 16 patients. All lesions were subject to ER, PR, HER2 and Ki67 immunohistochemistry and assigned a molecular subtype. The main aim was to compare DCIS of the two subtypes T...
ORGANISM(S): Homo sapiens 
2026-06-26 | E-MTAB-16918 | biostudies-arrayexpress
TranscriptomicsDevelopment of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
Mammary alveologenesis is abrogated in the absence of the transcription factors STAT5A/5B that mediate cytokine signaling. To reveal the underlying causes for this developmental block we studied mammary stem and progenitor cells. While loss of STAT5A/5B did not affect the stem cell population and ...
ORGANISM(S): Mus musculus 
2009-10-21 | E-GEOD-17723 | biostudies-arrayexpress
MetabolomicsCommensal intestinal microbiota regulates host luminal proteolytic activity and intestinal barrier integrity through β-glucuronidase activity (Part 1)
Not available
ORGANISM(S): Homo sapiens 
ST002094 | MetabolomicsWorkbench
TranscriptomicsDifferential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer model (SNP)
The cellular heterogeneity of one patient derived orthotopic breast cancer xenograft model PDX was investigated using flow cytometry, combined with assessment of in vivo tumorigenicity and SNP genotyping array for copy number analysis. Epithelial cell adhesion molecule (EpCAM) was revealed as a high...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-54595 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse normal mammary gland epithelial populations: basal/myoepithelial, luminal estrogen receptor negative (ER-) and luminal estrogen receptor positive (ER+) cells
The goal of the experiment was to carry out a transcriptome analysis of the three main epithelial cell populations of the mouse mammary gland, the basal/myoepithelial, luminal estrogen receptor negative (ER-) and luminal estrogen receptor positive (ER+) cells, to identify cell-type specific differen...
ORGANISM(S): Mus musculus 
2009-04-20 | E-TABM-683 | biostudies-arrayexpress
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