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Proteomic analysis of membrane fractions from U-2 OS control and Lunapark knockout cells to determine protein abundance per mRNA. Membrane proteins were extracted, digested, and analyzed by DIA LC–MS/MS on a Thermo Orbitrap Ascend Tribrid mass spectrometer with Vanquish Neo LC system
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD068879 | Pride
Secretome translation shaped by Lysosomes and Lunapark-marked ER Junctions
This study investigates how translation of mRNAs encoding membrane and secretory proteins (“secretome mRNAs”) is spatially regulated in human cells. Using live-cell imaging, proteomics, and RNA-sequencing, we show that Lunapark (LNPK)–enriched ER junctions and lysosomes form specialized hubs that en...
ORGANISM(S): Homo sapiens 
2025-09-30 | GSE309254 | GEO
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