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TranscriptomicsDetecting lung tumors from circulating microRNA profiles
We aimed to determine if lung cancer detection can be improved by circulating miRNAs as biomarkers. To this end, we collected blood of over 3000 individuals using PAXgene blood tubes. The individuals were diagnosed with lung cancer (LCa), a non-tumor lung disease (NTLD), another disease (OD) or were...
ORGANISM(S): Homo sapiens 
2020-05-19 | E-MTAB-8026 | biostudies-arrayexpress
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
TranscriptomicsTranscription profiling of C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD
Comparison of lung function in C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD.
ORGANISM(S): Mus musculus 
2007-03-08 | E-MEXP-855 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human bronchoalveolar lavage and lung biopsy samples in the segmental endotoxin challenge model
Segmental instillation of lipopolysaccharide (LPS) by bronchoscopy can be used as a model to safely induce transient airway inflammation in the human lung. The LPS challenge model enables investigation of cellular mechanisms involved in pulmonary inflammatory processes as well as pharmacodynamic ana...
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-13318 | biostudies-arrayexpress
UnknownATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation.
Not available
S-EPMC7449963 | biostudies-literature
UnknownIL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation.
Not available
S-EPMC5346180 | biostudies-literature
TranscriptomicsOvalbumin sensitized and challenged induces differential gene expression in mouse lungs
To gain insight into the promoting effect of ultrafine particle inhalation on development and progression of allergic asthma, we selected an experimental approach involving exposure to ultrafine carbon particles (UCP) and gene expression profiling of lungs from mice with experimental, ovalbumin indu...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-6496 | biostudies-arrayexpress
TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
TranscriptomicsUCP exposure of ovalbumin sensitized and challenged mice
To gain insight into the promoting effect of ultrafine particle inhalation on development and progression of allergic asthma, we selected an experimental approach involving exposure to ultrafine carbon particles (UCP) and gene expression profiling of lungs from mice with experimental, ovalbumin indu...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-6571 | biostudies-arrayexpress
GenomicsTranscriptome analysis in very preterm infants with chronic lung disease after birth
Bronchopulmonary dysplasia (BPD) is the most common complication of prematurity and is characterized by impaired alveolar and vascular development. The aim of the study was to identify early BPD-relevant pathways by applying whole genome transcriptional profiling combined with protein measurements f...
EGAS00001002586 | EGA
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