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TranscriptomicsSuppression of Lung Adenocarcinoma Progression by Nkx2-1
Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-p...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26874 | biostudies-arrayexpress
TranscriptomicsCLEFMA selectively induces necrotic cell death of H441 lung adenocarcinoma cells via oxidative stress
Despite the growing understanding about the molecular basis of oncogenesis, prevention and cure of cancer remains an unsurpassed challenge. Chemotherapeutic drugs are the mainstay in managing patients diagnosed with any form of cancer. The emergent chemo-resistance, morbid toxicities and overall ine...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-23420 | biostudies-arrayexpress
ProteomicsLung adenocarcinoma cell lines under HSP90 inhibitors and the proteomic technique iTRAQ
Protein profiling underlying the therapeutic efficacy of HSP90 inhibitors in human lung adenocarcinoma cell lines
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD040170 | Pride
Hsp90 inhibitors Nano lc-ms/ms analysis Human lung adenocarcinoma cell line Itraq labelling 
ProteomicsProteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma
Immune checkpoint inhibitor and adoptive lymphocyte transfer-based therapies have shown great therapeutic potential for cancers with high tumor mutation burden (TMB). Here, we employed mass spectrometry (MS)-based proteogenomic large-scale profiling to identify potential immunogenic human leukocyte ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD022949 | Pride
Hla immunopeptidome Immunotherapy Neoantigen Melanoma Lung cancer 
TranscriptomicsTranscription profiling of lung alveolar type II epithelial cells from CCSP-rtTA/(teto)7Stat3C bitransgenic mice treated with doxycycline and with spontaneous lung bronchoalveolar adenocarcinoma
Over-expression of Stat3C in lung alveolar type II epithelial cells of CCSP-rtTA/(teto)7Stat3C bitransgenic mice leads to severe pulmonary inflammation in the lung. As a consequence, spontaneous lung bronchoalveolar adenocarcinoma was observed in bitransgenic mice. Aberrantly expressed genes in th...
ORGANISM(S): Mus musculus 
2008-05-07 | E-MEXP-1137 | biostudies-arrayexpress
TranscriptomicsExpression data from AK4 overexpression in CL1-0 lung cancer cell line and AK4 knockdown in CL1-5 lung cancer cell line
We demonstrate that AK4 down-regulation shRNAs significantly reduced cell migration and invasion in highly invasive lung cancer cell lines in vitro, as well as in lung metastases in vivo We used microarrays to analyze the AK4 regulated gene expression underlying invasion-metastasis cascade. CL1-0 lu...
ORGANISM(S): Homo sapiens 
2012-12-03 | E-GEOD-37903 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung adenocarcinoma derived cell line A549 treated with dexamethasone
Effect of dexamethasone on gene expression in lung adenocarcinoma derived cell line A549
ORGANISM(S): Homo sapiens 
2010-01-05 | E-MEXP-2004 | biostudies-arrayexpress
TranscriptomicsGenomic changes in low vs high metastatic A549 NSCLC cell line
Genomic changes in low and highly metastatic A549 cells were analyzed by 500K SNP arrays. A large number of genomic alterations were present in A549 cells but no significant differences were observed between the low or highly metastatic A549 cell lines. We generated a NSCLC line with highly increase...
ORGANISM(S): Homo sapiens 
2013-02-21 | E-GEOD-44549 | biostudies-arrayexpress
ProteomicsQuantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V
Lung cancer is the leading cause of cancer death both in men and women. Tumor heterogeneity is an impediment to targeted treatment of all cancers, including lung cancer. Here, we sought to characterize changes in tumor proteome and phosphoproteome by longitudinal, prospective collection of tumor tis...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010779 | Pride
Lung adenocarcinoma Proteomic heterogeneity Quantitative mass spectrometry 
TranscriptomicsClaudin 1 mediates TNF alpha-induced gene expression and cell migration in human lung carcinoma cells
Epithelial-mesenchymal transition (EMT) is an important mechanism in carcinogenesis. To determine the mechanisms that are involved in the regulation of EMT is crucial to develop new biomarkers and therapeutic targets towards cancers. In this study, when TGFß1 and TNFa were used to induce EMT in hum...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-32254 | biostudies-arrayexpress
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