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MetabolomicsMulti-omics Analysis Reveals New Insights into Yak Lung Fibrosis Mechanisms Under High-Altitude Adaptation

The lung of yak is an important adaptive organ in the cold and low oxygen environment. Hypoxia can induce the pathological manifestations of pulmonary fibrosis in yak, but there was no study on hypoxia induced pulmonary fibrosis in yak. In this study full target metabolomics were used to conduct ...

2025-07-07 | MTBLS11648 | MetaboLights
MetabolomicsMulti-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
Cigarette smoke (CS) causes adverse health effects and leads to the development of respiratory disease (chronic obstructive pulmonary disease), cardiovascular disease, and cancer. To reduce the risk of smokers developing smoking-related diseases, Philip Morris International is developing modified ri...
2020-04-25 | MTBLS158 | MetaboLights
MetabolomicsThe Metabolic Fate of Oxaliplatin in the Biological Milieu Investigated During In Vivo Lung Perfusion Using a Unique Miniaturized Sampling Approach Based on Solid-Phase Microextraction Coupled with Liquid Chromatography-Mass Spectrometry

Adjuvant chemotherapy after pulmonary metastasectomy for colorectal cancer may reduce recurrence and improve survival rates; however, the benefits of this treatment are limited by the significant side effects that accompany it. The development of a novel in vivo lung perf...

2022-08-02 | MTBLS4982 | MetaboLights
ProteomicsProteomic analysis of lung tissues in an oleic acid (OA)-induced acute lung injury model rats
Data analyzed proteins extracted from lung tissue samples from OA-induced acute lung injury model rats. Samples were collected at 0 (pretreatment), 3, 6, 24, 48, 96 h after OA administration. Whole tissue extracts were prepared from three individuals and analyzed using the DIA-MS method.
ORGANISM(S): Cellular Organisms 
2025-03-14 | PXD057386 | JPOST Repository
TranscriptomicsAnti-Inflammatory Effects of Budesonide in Human Fetal Lung
Rationale. Lung inflammation in premature infants contributes to development of bronchopulmonary dysplasia (BPD), a chronic lung disease with long-term sequelae. Pilot studies administering budesonide suspended in surfactant have found reduced BPD without apparent adverse effects as occur with syste...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-83888 | biostudies-arrayexpress
ProteomicsCell sorted lipidomics and proteomics of the 20 month human lung
Applied liquid chromatography-tandem mass spectrometry to characterize the lipidome of major lung cell types isolated from human donors, representing the first lipidome map of any organ. We coupled this with cell type-resolved proteomics of the same samples (available at lungmap.net). Complementary ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-25 | MSV000081973 | MassIVE
ProteomicsAn atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the third leading cause of death worldwide. We used single cell transcriptomics and mass spectrometry to quantify changes in cellular activity states of 30 cell types and the tissue proteome from lungs of you...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-21 | PXD012307 | Pride
Lung Lipid metabolism Single cell transcriptomics Total proteome Qdsp Chronic lung disease Aging Lung cell atlas Extracellular matrix 
Proteomicscomparative proteomics of non-small cell lung cancer and small cell lung cancer
We aimed to identify the differences between these two subtypes of lung cancers and their differentially clinical treatment. Through functional analysis, we obtained differentially expressed proteins which might be assossciated with lung cancer treatment.
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD015270 | Pride
Lung cancer Proteomics Lc-mc/mc 
OtherIdentifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics.
Data from ProteomeXchange, PXD ID: PXD001101. Experiment: pST_SILAC_R1a, file: H3255_pST_SILAC_R1_F4_a.mzml. Published as part of Proteomics. 2015 Jan;15(2-3):340-55 . From the Abstract: {{i}} . We sought to identify the immediate direct and indirect phosphorylation targets of mutant EGFRs in lung ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320007613 | GPMDB
Resource Reanalysis 
ProteomicsProteomic analysis of nonsmall cell lung cancer
These data correspond to PMID: 22761400, "In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers." (Mol Cell Proteomics. 2012 Oct;11(10):916-32. Epub 2012 Jul 3.)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2013-11-18 | MSV000078491 | MassIVE
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