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ProteomicsAn atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the third leading cause of death worldwide. We used single cell transcriptomics and mass spectrometry to quantify changes in cellular activity states of 30 cell types and the tissue proteome from lungs of you...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-21 | PXD012307 | Pride
Lung Lipid metabolism Single cell transcriptomics Total proteome Qdsp Chronic lung disease Aging Lung cell atlas Extracellular matrix 
ProteomicsComprehensive proteome of the adult neural stem cell niche identifies key regulators of adult neurogenesis
Neural stem cells (NSCs) generating new neurons are restricted to few niches in the adult mammalian brain, while the remainder rather promotes gliogenesis. Here we take advantage of the spatial separation of an NSC niche (the subependymal zone) and the region to where the newly generated neurons mig...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-27 | PXD016632 | Pride
Brain Stem cells Extracellular matrix Neurogenesis 
UnknownTime- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair.
Not available
S-EPMC4547847 | biostudies-literature
ProteomicsComparison of extracellular matrix enrichment protocols for the improved characterization of the skin matrisome by mass spectrometry
Four protocols were adapted and compared to enrich extracellular matrix proteins from mouse skin: 1. compartmental enrichment; 2. chemical decellularization; 3. enzymatic decellularization using phospholipase A2; 4. quantitative detergent solubility profiling (QDSP). All four protocols were started ...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD025842 | Pride
Ecm enrichment protocols comparison Mouse skin matrisome 
ProteomicsTime and compartment resolved proteome profiling of the extracellular niche in lung injury and repair
The extracellular niche is a key regulator of tissue morphogenesis and repair, however, its composition is currently not well characterized. Quantitative mass spectrometry resolved the dynamics of 8366 proteins from total tissue and bronchioalveolar lavage fluid in the consecutive phases of repair u...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-21 | PXD001765 | Pride
Regeneration Proteomics Matrisome Fibrosis Repair 
ProteomicsCompartment-resolved proteomic analysis of mouse aorta during atherosclerotic plaque formation
Atherosclerosis leads to vascular lesions that involve major rearrangements of the vascular proteome, especially of the extracellular matrix (ECM). Using single aortas from ApoE knock out mice, we quantified formation of plaques by single-run, high-resolution mass spectrometry (MS)-based proteomics....
ORGANISM(S): Mus musculus (Mouse) 
2017-12-08 | PXD006752 | Pride
Ecm Mouse model Atherosclerosis Apoe Qdsp 
ProteomicsFilling the gaps – a call for comprehensive analysis of extracellular matrix of the glial scar in region- and injury-specific contexts
CNS injury results in chronic scar formation that interferes with function and inhibits repair. Extracellular matrix (ECM) is prominent in the scar and potently regulates cell behavior. However, comprehensive information about the ECM proteome is largely lacking, and region- as well as injury-specif...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD017478 | Pride
Central nervous system Macrophages Gliosis Brain injury Scarring Extracellular matrix 
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