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UnknownLuo Tong Formula Alleviates Diabetic Retinopathy in Rats Through Micro-200b Target.
Not available
S-EPMC7723456 | biostudies-literature
ProteomicsEndothelial OTUD1 promotes Ang II-induced vascular remodeling by deubiquitinating SMAD3
Understanding the molecular mechanisms of pathological vascular remodeling is important for treating cardiovascular diseases and complications. Recent studies have highlighted a role of deubiquitinases in vascular pathophysiology. In this study, we investigated the role of a deubiquitinase, OTUD1, i...
ORGANISM(S): Homo sapiens (Human) 
2022-12-24 | PXD037926 | Pride
Huvec  lc-ms/ms 
UnknownAnti-Inflammatory Effects of Ang-(1-7) in Ameliorating HFD-Induced Renal Injury through LDLr-SREBP2-SCAP Pathway.
Not available
S-EPMC4546194 | biostudies-literature
UnknownMacrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.
Not available
S-EPMC10282045 | biostudies-literature
UnknownMyeloid MyD88 Mediates Macrophage Infiltration and Activation in Ang II-Induced Cardiac Hypertrophy.
Not available
S-EPMC12274960 | biostudies-literature
UnknownLysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)-induced dissecting abdominal aortic aneurysm.
Not available
S-EPMC8490513 | biostudies-literature
ProteomicsDelineating Regions-of-interest forMass Spectrometry Imaging byMultimodally Corroborated Spatial Segmentation
Mass spectrometry imaging, which quantifies molecules in a tag-free, spatially-resolved manner, is a powerful tool for the understanding of underlying biochemical mechanisms of biological phenomena. When analyzing MSI data, it is essential to delineate Regions-of-Interest (ROIs) that correspond to t...
ORGANISM(S): Mus Musculus 
2023-03-08 | PXD038876 |
ProteomicsCardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling
Hypertensive heart failure highlights an urgent need for effective therapeutic strategies. Protein kinases regulate multiple pathways in cardiac pathophysiology and may provide promising therapeutic targets. Here, we identified a Cyclin-dependent kinase, CDK9, promoting inflammation and cardiac remo...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-15 | PXD074483 | Pride
Angiotensin ii  cdk9  nf-κb p65  cardiac remodeling  cardiomyocytes 
ProteomicsCardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling
Hypertensive heart failure highlights an urgent need for effective therapeutic strategies. Protein kinases regulate multiple pathways in cardiac pathophysiology and may provide promising therapeutic targets. Here, we identified a Cyclin-dependent kinase, CDK9, promoting inflammation and cardiac remo...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD074496 | Pride
Angiotensin ii  cdk9  nf-κb p65  cardiac remodeling  cardiomyocytes 
UnknownAngiogenin maintains gut microbe homeostasis by balancing α-Proteobacteria and Lachnospiraceae.
Not available
S-EPMC7904960 | biostudies-literature
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