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ProteomicsMyeloid-derived grancalcin instigates obesity-induced insulin resistance and metabolic inflammation
The crosstalk between the bone and adipose tissue orchestrates the metabolic homeostasis, but the underlying mechanisms are largely unknown. Herein, we find that GCA+(grancalcin) immune cells accumulate in the bone marrow and release a sufficient amount of GCA into circulation during obesity. Geneti...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-06 | PXD045836 | Pride
Grancalcin  insulin resistance  metabolic inflammation 
ProteomicsLiquid chromatography-tandem mass spectrometry analysis of bone marrow from the ground or running rats
Exercise can prevent osteoporosis and improve immune function, but the mechanism remains unclear. To explore the key factors involved in these two processes, we collected bone marrow from ground and running rats and then conducted liquid chromatography-tandem mass spectrometry.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-17 | PXD033807 | Pride
Fat metabolism Exercise Immunity Bone marrow fat Bone metabolism Lipolysis 
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