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MetabolomicsUrinary Extracellular Vesicle Metabolomic Profiling Reveals a Distinct Molecular Signature for the Non-Invasive Diagnosis of Lupus Nephritis

Background: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), underscoring an urgent need for non-invasive diagnostic biomarkers. 

Objective: This study aimed to define the metabolomic signature of urinary e...

2026-02-11 | MTBLS13839 | MetaboLights
TranscriptomicsEffect of Sirolimus treatment on lupus nephritis in NZB/W F1 female mice
NZB/WF1 female mice spontaneously develop autoimmune lupus nephritis. Expression profiling of kidney tissue from (a) 12 week NZB/W F1 female mice defined as asymptomatic for lupus nephritis, (b) 36 and 42 week NZB/W F1 female mice defined as diseased/symptomatic for lupus nephritis and (c) 36 and 42...
ORGANISM(S): Mus musculus 
2008-11-20 | E-GEOD-12024 | biostudies-arrayexpress
MetabolomicsFecal Metabolomics and Potential Biomarkers for Systemic Lupus Erythematosus
The role of metabolomics in autoimmune diseases has been a rapidly expanding area in researches over the last decade, while its pathophysiologic impact on systemic lupus erythematosus (SLE) remains poorly elucidated. In this study, we analyzed the metabolic profiling of fecal samples from SLE patien...
2020-01-30 | MTBLS916 | MetaboLights
TranscriptomicsHuman and mouse lupus nephritis cross-species transcriptional analysis
This SuperSeries is composed of the following subset Series: GSE32583: Expression data from lupus NZB/W, NZM2410, NZW/BXSB mouse kidneys prenephritic and nephritic. GSE32591: Expression data from human with lupus nephritis (LN) Refer to individual Series
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-32592 | biostudies-arrayexpress
TranscriptomicsNanostring Immunology V2 panel comparing expression in kidney tissue from lupus nephritis patients at diagnosis (A) and at flare (B)
The purpose of the experiment was to compare the transcriptional profile of lupus nephritis kidney tissue at a first flare and expression at a repeated lupus nephritis episode. All samples were laser microdissected into glomerular and tubular compartments and samples were ran in different cartridges...
ORGANISM(S): Homo sapiens 
2018-04-19 | E-GEOD-113342 | biostudies-arrayexpress
MetabolomicsComparative 1H-NMR Lipoprotein Profiling of Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Highlights Disease-Specific Lipoprotein Dysregulation

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic autoimmune diseases associated with increased cardiovascular risk and metabolic alterations. We applied 1H-NMR spectroscopy to profile lipoproteins and metabolites in women with RA, SLE, and healthy controls. Both RA an...

2026-02-02 | MTBLS13820 | MetaboLights
TranscriptomicsMicroarray of whole human kidneys from lupus nephritis patients
GeneSet variation analysis was performed on microarrays to study the transcriptome of microdissected renal biopsies from lupus nephritis patients.
ORGANISM(S): Homo sapiens 
2023-01-01 | E-MTAB-12257 | biostudies-arrayexpress
MetabolomicsCharacteristics of steroid hormones in systemic lupus erythematosus revealed by GC/MS-based metabolic profiling

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a remarkable predominance in female, suggesting that steroid hormones may be involved in the pathogenesis. Herein, more than 70 kinds of steroids in urine were detected by gas chromatography/mass spectrometry (GC/MS) to reve...

2023-07-28 | MTBLS7766 | MetaboLights
TranscriptomicsExpression data from lupus NZB/W, NZM2410, NZW/BXSB mouse kidneys prenephritic and nephritic.
Nephritis (LN) is a serious manifestation of SLE. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these models. In this study we used an unbiased transcriptional network approach to define similarities a...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-32583 | biostudies-arrayexpress
ProteomicsDiscovery of Novel Circulating Immune Complexes in Lupus Nephritis Using Immunoproteomics
The goal is to discover novel circulating immune complexes (ICx) in the serum of Lupus Nephritis (LN) as potential biomarkers. Protein A/G magnetic beads or C1q-coated plates were used to capture ICx in the serum of LN, followed by the identification of immunoglobulin-binding proteins using liquid c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031069 | Pride
Human Ms/ms Serum Lupus nephritis 
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