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ProteomicsProteome / pYome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD030582 | Pride
Lyn kinase Hs-5 Stroma Bmsc Secretome Multi-omics 
GenomicsDeep phenotyping by mass cytometry and single cell RNA-sequencing reveals LYN regulated signaling profiles underlying monocyte subset heterogeneity and lifespan
Deep phenotyping by mass cytometry and single cell RNA-sequencing reveals LYN regulated signaling profiles underlying monocyte subset heterogeneity and lifespan
PRJNA609722 | ENA
UnknownThe Src-family Kinase Lyn in Immunoreceptor Signaling.
Not available
S-EPMC8389176 | biostudies-literature
UnknownNeuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts.
Not available
S-EPMC4401789 | biostudies-literature
UnknownCARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases.
Not available
S-EPMC7546115 | biostudies-literature
UnknownNa/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.
Not available
S-EPMC9442361 | biostudies-literature
TranscriptomicsDeep phenotyping by mass cytometry and single cell RNA-sequencing reveals LYN regulated signaling profiles underlying monocyte subset heterogeneity and lifespan
Rationale: Monocytes are key effectors of the mononuclear phagocyte system (MPS), playing critical roles in regulating tissue homeostasis and coordinating inflammatory reactions, including those involved in chronic inflammatory diseases such as atherosclerosis. Monocytes have traditionally been divi...
ORGANISM(S): Mus musculus 
2020-05-04 | GSE146216 | GEO
GenomicsMacrophage Lyn kinase is a Sex-Specific Regulator of Post-SAH Neuroinflammation
Macrophage Lyn kinase is a Sex-Specific Regulator of Post-SAH Neuroinflammation
PRJNA1213855 | ENA
OtherMacrophage Lyn kinase is a Sex-Specific Regulator of Post-SAH Neuroinflammation
Lyn kinase is a member of the Src family of tyrosine kinases, primarily known for its role in regulating immune cell signaling. It can phosphorylate and modulate the activity of various proteins involved in immune responses, including TLR4. In our study, we investigated the sex-specific involvement ...
ORGANISM(S): Mus musculus 
2026-01-21 | GSE287635 | GEO
UnknownLuxeptinib interferes with LYN-mediated activation of SYK and modulates BCR signaling in lymphoma.
Not available
S-EPMC9994718 | biostudies-literature
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