Lys-c endopeptidase

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Center for Immunity and Immunotherapies, Seattle Children's Research Institute. Department of Pediatrics, University of Washington. Seattle, WA USA (2)
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Division of Biochemistry, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Staudtstr 5, D-91058 Erlangen, Germany (2)
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Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany. (2)
Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan (2)
Proteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark (2)
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1 - College of Pharmacy, University of Sharjah, Sharjah 2 - Sharjah Institute for Medical Research, University of Sharjah, Sharjah (1)
1 Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA (1)
1 Institute for Integrated Stress Response Signaling, Faculty of Medicine, University Hospital Cologne, Cologne, Germany 2 Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany (1)
1 VIB Center for Medical Biotechnology, VIB, Ghent, East Flanders, 9052, Belgium 2 Department of Biomolecular Medicine, Ghent University, Ghent, East Flanders, 9052, Belgium (1)
1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands (1)
1Departments of Medicine & 2Pathology, Case Western Reserve University and University Hospitals Case Medical Center; 3Department of Molecular Biology & Microbiology Case Western Reserve University School of Medicine, Cleveland, Ohio 44106,USA. (1)
Associate Professor, Deparment of Neurology, Emory University (1)
Associate Professor, Department of Neurology, Emory University (1)
Associate Professor, Department of Neurology, Yale University School of Medicine (1)
Associate Professor, Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center (1)
Associate Research Fellow, Institute of Plant and Microbial Biology Academia Sinica, Taipei, Taiwan (1)
Biochemistry and Molecular Biology, University of British Columbia, Canada (1)

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Extending the coverage of Lys-C/trypsin-based bottom-up proteomics using cysteine S-aminoethylation

In this study, S-aminoethylation of Cys (AE-Cys) was carried out with 2-bromoethylamine to form pseudo-Lys, which was then digested with Lys-C or trypsin to improve proteome coverage in bottom-up proteomics. A model study with bovine serum albumin showed that the C-terminal side of Cys was successfu...

ORGANISM(S): Homo Sapiens (human) Bos Taurus

2023-09-27 | PXD045433 | JPOST Repository

Reversible Lysine Derivatization Enables High Specificity of Arg-C Digestion Using Trypsin

Bottom-up proteomics approach has become an important strategy in diverse areas of biological research, and the enzymatic digestion is essential for this technology. Endopeptidase Arg-C catalyzing the hydrolytic cleavage of peptide bonds C-terminal to arginine could be an important protease in botto...

ORGANISM(S): Homo sapiens (Human) Escherichia coli

2018-01-04 | PXD007994 | Pride

Imaging asparaginyl endopeptidase (AEP) in the live brain as a biomarker for Alzheimer's disease.

Not available

S-EPMC8375181 | biostudies-literature

Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1.

Not available

S-EPMC6663877 | biostudies-literature

Characterization of member of DUF1888 protein family, self-cleaving and self-assembling endopeptidase.

Not available

S-EPMC3365983 | biostudies-literature

Optimisation of Synovial Fluid Collection and Processing for NMR Metabolomics and LC-MS/MS Proteomics

Synovial fluid (SF) is of great interest for the investigation of orthopaedic pathologies as it is in close proximity to various tissues which are primarily altered during these disease processes and can be collected using minimally invasive protocols. Therefore, SF has substantial potential for imp...

ORGANISM(S): Equus caballus (Horse)

2020-04-06 | PXD017069 | Pride

Metabolomics Mass spectrometry Synovial fluid Nuclear magnetic resonance Proteomics Lys-c endopeptidase

Extracellular proteolytic activation of Pseudomonas aeruginosa aminopeptidase (PaAP) and insight into the role of its non-catalytic N-terminal domain.

Not available

S-EPMC8208579 | biostudies-literature

Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation.

Not available

S-EPMC12019160 | biostudies-literature

Release of protein A from the cell wall of Staphylococcus aureus.

Not available

S-EPMC3910568 | biostudies-literature