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ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-09 | MSV000081704 | MassIVE
TranscriptomicsTranscription profiling of embryonic stem cells from wild type and histone deacetylase 1 (HDAC1) knock out mice to identify putative HDAC1 target genes.
Histone deacetylase 1 (HDAC1) is an enzyme that promotes deacetylation of acetylated lysine residues in histones and other proteins. Histone acetylation is often associated with gene activation and expression. Los of HDAC1 leads to severe problems in development and proliferation. Moreover, it seems...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5583 | biostudies-arrayexpress
ProteomicsUnraveling Lysine Deacetylase Inhibitor Specificities for Endogenous Acetylation Sites
Lysine deacetylases (KDACs) are important regulators of biological processes. KDAC inhibitors (KDACIs) are important tools for basic research and attractive therapeutic candidates, yet their effects on in-vivo acetylation sites are poorly known. Here we obtained acetylation signatures for 19 differe...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-02-16 | PXD001377 | Pride
Proteomics Bufexamac Mass spectrometry Silac Nicotinamide Hdac Acetylation Tenovin-6 Kdac Sirtuin Deacetylase inhibitor 
ProteomicsEffects of lysine deacetylase inhibitor treatment on LPS responses of alveolar-like macrophages
Macrophages are key immune cells in tissues that are able to adapt their metabolic phenotype in response to different stimuli. Lysine deacetylases are important enzymes for regulating inflammatory gene expression and their inhibitors have anti-inflammatory effects in models of chronic obstructive pu...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-21 | PXD040933 | Pride
Dia proteomics Alveolar-like macrophages Lps activation Kdac inhibition Mouse 
TranscriptomicsH3K9K14ac ChIP-chip in lung cancer cells treated with histone deacetylase inhibitor
Lung cancer is the leading cause of cancer mortality worldwide, yet the therapeutic strategy for advanced non-small cell lung cancer (NSCLC) is limitedly effective. In addition, validated histone deacetylase (HDAC) inhibitors for the treatment of solid tumors remain to be developed. Here, we propose...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-20304 | biostudies-arrayexpress
ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo sapiens (Human) 
2017-09-12 | PXD005903 | Pride
Deacetylase inhibitor Sirt1 Cancer cells Lysine acetylation Stoichiometry Proteomics 
TranscriptomicsRNA expression in MDA-MB-231 cells treated for 24h with SAHA, Pargyline, or both [HG-U133A_2]
Abnormal activities of histone lysine demethylases (KDMs) and lysine deacetylases (HDACs) are associated with aberrant gene expression in breast cancer development. However, the precise molecular mechanisms underlying the crosstalk between KDMs and HDACs in chromatin remodeling and regulation of gen...
ORGANISM(S): Homo sapiens 
2015-09-04 | E-GEOD-72688 | biostudies-arrayexpress
ProteomicsDecrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
Lysine deacetylase inhibitors (KDACis) are approved for cutaneous T-cell lymphoma (CTCL) and multiple myeloma. Nevertheless, their mechanisms of action (MoA) remain elusive. To characterize the MoA of these drugs in more detail, we systematically measured dose-dependent changes in protein expression...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-08 | MSV000093608 | MassIVE
ProteomicsQuantitative analysis of the Arabidopsis thaliana leaf acetylome after treatment with deacetylase inhibitors trichostatin A and apicidin
Lysine acetylation is a common post-translational modification in eukaryotes and prokaryotes which is known to be involved in the regulation of various cellular processes, such as transcriptional activation, metabolic signaling, and energy homeostasis. Nevertheless, its role in plant primary metabol...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-10-25 | PXD006695 | Pride
Lysine acetylation Arabidopsis Photosynthesis Histone deacetylases Rubisco activase 
ProteomicsDecrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T-cell lymphoma (CTCL) and multiple myeloma. The drugs lead to increasing acetylation levels of histones and other proteins, altered gene expression, and cell death. To characterize the mechanisms of action of these drugs in mor...
ORGANISM(S): Homo Sapiens 
PXD047419 | panorama
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