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ProteomicsLysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals
We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenou...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD058513 |
ProteomicsA Proteome-Wide Atlas of Lysine-Reactive Chemistry
Recent advances in chemical proteomics have begun to characterize the reactivity and ligandability of lysines on a global scale. Yet, only a limited diversity of aminophilic electrophiles have been evaluated for interactions with the lysine proteome. Here, we report an in-depth profiling of >30 unch...
ORGANISM(S): Homo sapiens (Human) 
2021-09-20 | PXD025829 | Pride
Human immune cells Lysine reactive probes 
ProteomicsTunable activated esters for lysine labeling in proteome
The development of various heteroaromatic activated esters designed for selective lysine labeling within the proteome for profiling purposes. Through systematic optimization of the reactivity and selectivity of these esters, we identified a series of effective probe molecules suitable for both in vi...
ORGANISM(S): Homo Sapiens 
PXD051323 |
UnknownEnzymatic synthesis of reactive RNA probes containing squaramate-linked cytidine or adenosine for bioconjugations and cross-linking with lysine-containing peptides and proteins.
Not available
S-EPMC11696893 | biostudies-literature
UnknownTunable Amine-Reactive Electrophiles for Selective Profiling of Lysine.
Not available
S-EPMC10111338 | biostudies-literature
UnknownAssessing Squarates as Amine-Reactive Probes.
Not available
S-EPMC10935565 | biostudies-literature
ProteomicsMultiplexed CuAAC-Suzuki-Miyaura for tandem activity-based chemoproteomic profiling
Suzuki-Miyauara cross-coupling has been used for mass-spectrometry-based chemoproteomics, including for target deconvolution and site of labeling studies. We also demonstrated that Suzuki-Miyauara cross coupling and CuAAC can be combined for dual target labeling for mass spectrometry-based proteomic...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD022279 | Pride
Multiplexed cuaac suzuki-miyaura chemoproteomics Sp3 cleanup Suzuki-miyauara cross-coupling 
UnknownControl of Probe Density at DNA Biosensor Surfaces Using Poly(l-lysine) with Appended Reactive Groups.
Not available
S-EPMC6302315 | biostudies-literature
UnknownMaterial-Selective Deposition of Reactive Group-Functionalized Poly‑l‑lysine for DNA Sensing at Optical Waveguides.
Not available
S-EPMC12676348 | biostudies-literature
TranscriptomicsLysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals
Bromodomain (BRD) is an epigenetic reader of acetylated lysine. It has emerged as a therapeutic target for cancer and other diseases. Current nonselective BRD inhibitors (BRDis) face several adverse events (i.e. gastrointestinal toxicity and thrombocytopenia), making the development of target covale...
ORGANISM(S): Homo sapiens 
2024-12-11 | GSE283487 | GEO
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