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GenomicsLiver lipophagy ameliorates nonalcoholic steatohepatitis through lysosomal lipid exocytosis
Liver lipophagy ameliorates nonalcoholic steatohepatitis through lysosomal lipid exocytosis
PRJNA771352 | ENA
GenomicsGalns-deficiency enhances lysosomal exocytosis and alters cartilage development in zebrafish
Galns-deficiency enhances lysosomal exocytosis and alters cartilage development in zebrafish
PRJNA1282735 | ENA
ProteomicsMYO18B promotes lysosomal exocytosis by facilitating focal adhesion maturation
Many cancer cells exhibit increased amounts of paucimannose glycans, which are truncated N-glycan structures rarely found in mammals. Paucimannosidic proteins are proposedly generated within lysosomes and exposed on the cell surface through a yet uncertain mechanism. In this study, we assured that p...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD051592 | Pride
Paucimannose Glycoproteomics Lysosome Hela Hek293 Thp1 Myo18b 
GenomicsEpidrug Screening Identifies Type I PRMT Inhibitors as Modulators of Lysosomal Exocytosis and Drug Sensitivity in Cancers
Epidrug Screening Identifies Type I PRMT Inhibitors as Modulators of Lysosomal Exocytosis and Drug Sensitivity in Cancers
PRJNA1162511 | ENA
GenomicsOCaR1, a gatekeeper of lysosomal and granular Ca2+ release and regulated exocytosis
OCaR1, a gatekeeper of lysosomal and granular Ca2+ release and regulated exocytosis
PRJNA434189 | ENA
TranscriptomicsLiver lipophagy ameliorates nonalcoholic steatohepatitis through lysosomal lipid exocytosis
Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid accumulation and subsequent inflammatory and profibrotic response. Lipid reduction through cytoplasmic lipolysis might adversely worsen steatohepatitis, however, the effect of autophagic lipolysis, lipophagy, remains o...
ORGANISM(S): Mus musculus 
2023-05-15 | GSE185911 | GEO
TranscriptomicsEpidrug Screening Identifies Type I PRMT Inhibitors as Modulators of Lysosomal Exocytosis and Drug Sensitivity in Cancers
Epigenetic changes drive differential gene expression, contributing to oncogenic transformation and drug resistance. Lysosomes are crucial in cell signaling and the sequestration of toxins and chemotherapeutic agents. This sequestration followed by expulsion through lysosomal exocytosis is a factor ...
ORGANISM(S): Homo sapiens 
2025-08-13 | GSE277490 | GEO
TranscriptomicsLysosomal exocytosis by macrophages as a druggable mechanism for anti-inflammatory clearance of dead adipocytes in adipose tissue
The clearance of dead adipocytes in adipose tissue (AT) poses a major challenge due to their large size, which exceeds the phagocytic capacity of macrophages and prevents classical, anti-inflammatory efferocytosis. Instead, adipose tissue macrophages (ATMs) accumulate around dying adipocytes, formin...
ORGANISM(S): Mus musculus 
2025-09-03 | GSE307090 | GEO
TranscriptomicsGalns-deficiency enhances lysosomal exocytosis and alters cartilage development in zebrafish
Lysosomes represent a heterogenous population of organelles whose optimal function is essential for early tissue development. The importance of this is evidenced by the number of inherited disorders, collectively called the lysosomal storage disorders (LSDs), caused by lysosomal dysfunction. While i...
ORGANISM(S): Danio rerio 
2026-02-06 | GSE300957 | GEO
UnknownRegulated lysosomal exocytosis mediates cancer progression.
Not available
S-EPMC4730843 | biostudies-literature
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