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GenomicsBioresponsive lysosome-targeting chimeras for targeted protein degradation
Bioresponsive lysosome-targeting chimeras for targeted protein degradation
PRJNA1256450 | ENA
ProteomicsCellular determinants of targeted membrane protein degradation by lysosome targeting chimeras
Targeted protein degradation is a powerful therapeutic strategy that offers benefits over canonical target inhibition. Lysosome targeting chimeras (LYTACs) harness lysosome trafficking receptors such as the cation-independent mannose-6-phosphate receptor (CI-M6PR) to direct secreted and membrane pro...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037899 | Pride
Dia Lytac Quantitative proteomics Lysosome Crispri 
UnknownPolymeric Lysosome-Targeting Chimeras (PolyTACs): Extracellular Targeted Protein Degradation without Co-Opting Lysosome-Targeting Receptors.
Not available
S-EPMC12903612 | biostudies-literature
UnknownAptamer-Mediated Covalent Dual Lysosome-Targeting Chimeras Enhance Targeted Degradation of Cell Surface Proteins.
Not available
S-EPMC12848693 | biostudies-literature
TranscriptomicsBioresponsive lysosome-targeting chimeras for targeted protein degradation
Lysosome-mediated degradation of extracellular proteins represents an emerging therapeutic paradigm that exploits cellular waste-disposal machinery to eliminate pathogenic targets. Despite its promise, achieving selective degradation of disease-associated proteins remains constrained by the scarcity...
ORGANISM(S): Homo sapiens 
2025-05-01 | GSE295826 | GEO
UnknownEngineering IGF2 for Lysosome-targeting chimeras development to target drug-resistant membrane proteins in tumor therapy.
Not available
S-EPMC11837023 | biostudies-literature
ProteomicsDevelopment of polyvalent folate receptor-targeting chimeras (FRTACs) for lysosomal degradation of membrane proteins
Lysosome-targeting chimeras (LYTACs) have emerged as a revolutionary targeted protein degradation (TPD) technology in modulating the levels of extracellular and membrane proteins. However, lack of lysosome-trafficking receptors (LTRs) limits the development of LYTACs. Here, we firstly confirm that f...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD058539 | Pride
Lysosome-targeting chimeras Polyvalent strategy Targeted protein degradation Folate receptor 
ProteomicsDevelopment of polyvalent folate receptor-targeting chimeras (FRTACs) for lysosomal degradation of membrane proteins
Lysosome-targeting chimeras (LYTACs) have emerged as a revolutionary targeted protein degradation (TPD) technology in modulating the levels of extracellular and membrane proteins. However, lack of lysosome-trafficking receptors (LTRs) limits the development of LYTACs. Here, we firstly confirm that f...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD058523 | Pride
Lysosome-targeting chimeras Polyvalent strategy Targeted protein degradation Folate receptor 
ProteomicsDevelopment of polyvalent folate receptor-targeting chimeras (FRTACs) for lysosomal degradation of membrane proteins
Lysosome-targeting chimeras (LYTACs) have emerged as a revolutionary targeted protein degradation (TPD) technology in modulating the levels of extracellular and membrane proteins. However, lack of lysosome-trafficking receptors (LTRs) limits the development of LYTACs. Here, we firstly confirm that f...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD058514 | Pride
Lysosome-targeting chimeras Polyvalent strategy Targeted protein degradation Folate receptor 
UnknownLysosome-targeting chimeras containing an endocytic signaling motif trigger endocytosis and lysosomal degradation of cell-surface proteins.
Not available
S-EPMC11459673 | biostudies-literature
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