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UnknownA Self-Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple-Negative Breast Cancer Therapy.
Not available
S-EPMC12199414 | biostudies-literature
ProteomicsCellular determinants of targeted membrane protein degradation by lysosome targeting chimeras
Targeted protein degradation is a powerful therapeutic strategy that offers benefits over canonical target inhibition. Lysosome targeting chimeras (LYTACs) harness lysosome trafficking receptors such as the cation-independent mannose-6-phosphate receptor (CI-M6PR) to direct secreted and membrane pro...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037899 | Pride
Dia Lytac Quantitative proteomics Lysosome Crispri 
UnknownHarnessing Bone-Liver Crosstalk: A Dual-Action LYTAC Approach for Bone-Specific Accumulation and Liver-Specific Protein Degradation in Bone Disorders.
Not available
S-EPMC12728634 | biostudies-literature
ProteomicsDevelopment of polyvalent folate receptor-targeting chimeras (FRTACs) for lysosomal degradation of membrane proteins
Lysosome-targeting chimeras (LYTACs) have emerged as a revolutionary targeted protein degradation (TPD) technology in modulating the levels of extracellular and membrane proteins. However, lack of lysosome-trafficking receptors (LTRs) limits the development of LYTACs. Here, we firstly confirm that f...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD058539 | Pride
Lysosome-targeting chimeras Polyvalent strategy Targeted protein degradation Folate receptor 
ProteomicsDevelopment of polyvalent folate receptor-targeting chimeras (FRTACs) for lysosomal degradation of membrane proteins
Lysosome-targeting chimeras (LYTACs) have emerged as a revolutionary targeted protein degradation (TPD) technology in modulating the levels of extracellular and membrane proteins. However, lack of lysosome-trafficking receptors (LTRs) limits the development of LYTACs. Here, we firstly confirm that f...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD058523 | Pride
Lysosome-targeting chimeras Polyvalent strategy Targeted protein degradation Folate receptor 
ProteomicsDevelopment of polyvalent folate receptor-targeting chimeras (FRTACs) for lysosomal degradation of membrane proteins
Lysosome-targeting chimeras (LYTACs) have emerged as a revolutionary targeted protein degradation (TPD) technology in modulating the levels of extracellular and membrane proteins. However, lack of lysosome-trafficking receptors (LTRs) limits the development of LYTACs. Here, we firstly confirm that f...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD058514 | Pride
Lysosome-targeting chimeras Polyvalent strategy Targeted protein degradation Folate receptor 
UnknownElucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras.
Not available
S-EPMC10766146 | biostudies-literature
TranscriptomicsBioresponsive lysosome-targeting chimeras for targeted protein degradation
Lysosome-mediated degradation of extracellular proteins represents an emerging therapeutic paradigm that exploits cellular waste-disposal machinery to eliminate pathogenic targets. Despite its promise, achieving selective degradation of disease-associated proteins remains constrained by the scarcity...
ORGANISM(S): Homo sapiens 
2025-05-01 | GSE295826 | GEO
Genomics
RNA-seq of 2-month mouse tumor
PRJNA1364295 | ENA
UnknownDirected Evolution of Genetically Encoded LYTACs for Cell-Mediated Delivery.
Not available
S-EPMC10680704 | biostudies-literature
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